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  1. Multiple myeloma is a hematological malignancy of plasma cells belonging to a spectrum of monoclonal protein-secreting disorders known as paraproteinemias. It is classically characterized by accumulated plasma...

    Authors: Erick Thokerunga, Christopher Ntege and Abdullahi Omar Ahmed
    Citation: The Egyptian Journal of Internal Medicine 2021 33:54
  2. HCV infection is a major health concern. Disease progression to fibrosis, cirrhosis, and HCC is aided by the persistence of inflammatory reactions and cellular damage. Moreover, angiogenesis was found to have ...

    Authors: Amira Isaac, Tarek Maged El Sakaty, Sarah Hamdan Hussein and Hany Samir Rasmy
    Citation: The Egyptian Journal of Internal Medicine 2021 33:53
  3. Pyoderma gangrenosum (PG) is a rare and chronic neutrophilic dermatosis. It is clinically characterized by aseptic ulcerations preferentially located in the lower limbs. Its location in the genital area is unu...

    Authors: Hassina Chicha, Said Taharboucht, Nacera Tiboune, Nadia Touati and Ahcene Chibane
    Citation: The Egyptian Journal of Internal Medicine 2021 33:52
  4. Adolescents with coronavirus disease 2019 (COVID-19) associated multisystem inflammatory syndrome (MIS) can present with shock and myocardial injury and mimic Kawasaki disease.

    Authors: Rahul D. Bhiwgade, M. C. Nischitha, Bhushan Shahare and Shobhna Bitey
    Citation: The Egyptian Journal of Internal Medicine 2021 33:51
  5. Mycobacterium massiliense is a rapidly growing a non-tuberculous mycobacterium that has been validated as a separate species from the Mycobacterium abscessus group. Only few antibiotics have demonstrated germicid...

    Authors: Haroon Nawaz, Ayesha A. Choudhry and William Morse
    Citation: The Egyptian Journal of Internal Medicine 2021 33:39
  6. Endometriosis is a condition in which tissue similar to the lining inside the uterus (called “the endometrium”) is found outside the uterus, where it induces a chronic inflammatory reaction that may result in ...

    Authors: Nadia Abdelaaty Abdelkader, Ahmed F. Sherief, Enass Mohamed Soliman, Mahmoud Elsamman, Salah T. Fayed and Mohamed A. Sakr
    Citation: The Egyptian Journal of Internal Medicine 2021 33:50
  7. Psoriasis is a multisystem inflammatory disorder with variable morphology, clinical pattern and multiple comorbidities. Interplay between genetic and environmental factors leading to an aberrant immune respons...

    Authors: Enas Zahran, Ali Youssof, Wafaa Shehata, Ahmed Bahgat and Emad Elshebiny
    Citation: The Egyptian Journal of Internal Medicine 2021 33:49
  8. Early management of sepsis in the emergency department improves patient outcomes. The identification of at-risk patients for aggressive management by an easily available biomarker could go a long way in the tr...

    Authors: Mir Nadeem, Bilal Ahmad Mir, Mir Waseem, Tabinda Ayub Shah and Rameez Raja
    Citation: The Egyptian Journal of Internal Medicine 2021 33:48
  9. Co-occurrence of Type II Abernethy malformation (AM) with Type 1 pulmonary hypertension (PH) is extremely rare. In these patients, management of AM leads to reversal of PH.

    Authors: Arjun Agarwal, Durvesh Bhangale, Vinayak M. Sawardekar and Srikar Puvvada
    Citation: The Egyptian Journal of Internal Medicine 2021 33:38
  10. In this pandemic of COVID-19, the highest amount of infective material, biomedical waste is generated in hospitals and it is frequently handled by the healthcare workers irrespective of cadres. Hence the aware...

    Authors: T. J. Basavaraj, B. L. Shashibhushan and Amala Sreedevi
    Citation: The Egyptian Journal of Internal Medicine 2021 33:37
  11. Alzheimer’s disease (AD), cardiovascular disease (CVD), and diabetes are some of the most common causes of morbidity and mortality among the aging populations and cause a heavy burden on the worldwide healthca...

    Authors: Agnila Chakraborty, Saad Ahmed Sami and Kay Kay Shain Marma
    Citation: The Egyptian Journal of Internal Medicine 2021 33:47
  12. Hepatocellular carcinoma is a highly prevalent tumor worldwide. Amphiregulin is a ligand of the epidermal growth factor receptor. Its elevation is linked to different inflammatory and neoplastic conditions. Th...

    Authors: Amira Isaac, Sherif Mounir Mohamed, Osama Ashraf Ahmed, Ahmed Gamal Mohamed Hassan and Hany Samir Rasmy
    Citation: The Egyptian Journal of Internal Medicine 2021 33:46
  13. The association between hepatitis C virus (HCV), insulin resistance (IR), and metabolic syndrome has been extensively investigated. Direct-acting antivirals (DAAs) have a high sustained virologic response (SVR...

    Authors: Tarek Yosef, Wesam Ahmed Ibrahim, Ahmed El-Ghandour, Soha Attia and Sarah El-Nakeep
    Citation: The Egyptian Journal of Internal Medicine 2021 33:45
  14. Hypercalcemia is known to cause acute kidney injury (AKI). Literature related to hypercalcemic AKI is predominantly in the form of case reports and case series. The purpose of this study is to find the inciden...

    Authors: Nucksheeba Aziz Bhat, Farhat Mustafa, Rayees Yousuf Sheikh and Imtiyaz Wani
    Citation: The Egyptian Journal of Internal Medicine 2021 33:36
  15. Hodgkin’s lymphoma presenting with digital ischemia and gangrene is a rare manifestation. Paraneoplastic manifestations are rare in Hodgkin’s lymphoma but can occur in the form of paraneoplastic cerebellar deg...

    Authors: Swaroopa Deme, Bhaskar Kakarla, Venkateswar Rao P., Raju YSN and Nageswara Rao M.
    Citation: The Egyptian Journal of Internal Medicine 2021 33:44
  16. Indirect calorimetry is the reference method for measuring resting energy expenditure (REE), but the necessary equipment and technical expertise are not always available. Meanwhile, the NUTrition Risk in the C...

    Authors: Elham Sobhy, Radwa Abdel Kader, Alshaimaa Aboulfotouh, Mohammed Eshra and Mohamed Sayed
    Citation: The Egyptian Journal of Internal Medicine 2021 33:35
  17. Diabetes is a rapidly growing health problem worldwide. In 2019, the International Diabetes Federation (IDF) estimates that Egypt is the 9th country worldwide with about 8,850,400 cases and a prevalence of 15....

    Authors: Mai Mohamed Azzam, Adel Alwehedy Ibrahim and Mohammed I. Abd El-Ghany
    Citation: The Egyptian Journal of Internal Medicine 2021 33:33
  18. Coronavirus disease 2019 (COVID-19) is a recent pandemic infectious disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). COVID-19 may lead to acute kidney injury (AKI).

    Authors: Hayder M. Al-kuraishy and Ali I. Al-Gareeb
    Citation: The Egyptian Journal of Internal Medicine 2021 33:34
  19. Hepatitis C virus and nonalcoholic steatohepatitis (NASH) are the most common causes of liver cirrhosis in Egypt. Increasing aging population is a worldwide issue, and societies are facing various problems, in...

    Authors: Ahmed Abdelghani, Maha Hosam El-Din Ibrahim, Osama Mohamady Mohamed, Sobhi Eid Rizk and Rabab Mahmoud Ahmed
    Citation: The Egyptian Journal of Internal Medicine 2021 33:32
  20. Acute-on-chronic liver failure (ACLF) has been recently defined as a clinical form including acute hepatic decompensation and high 28-day mortality. ACLF usually follows a precipitating event on the background...

    Authors: Marwa Lotfi El Sayed, Tarek El Sayed Gouda, E. L. Sayed Abdel Maksood Khalil, Mohammed Mohammed El Sayed Al Arman and Islam Eid Mohamed
    Citation: The Egyptian Journal of Internal Medicine 2021 33:31
  21. Diabetes mellitus (DM) is a chronic disease with debilitating complications. Patients with diabetes are recommended to take various self-management decisions and carry out complex care activities. Diabetes sel...

    Authors: Reham Abo Emara, Madeha Hamed, Mohamed Awad and Wael Zeid
    Citation: The Egyptian Journal of Internal Medicine 2021 33:30
  22. Angiogenesis is the development of new blood vessels from the existing vasculature, which is important in normal developmental processes. Angiogenesis is a key step in tumor growth, invasion, and metastasis. A...

    Authors: Gowtham Kumar Subbaraj, Yasam Santhosh Kumar and Langeswaran Kulanthaivel
    Citation: The Egyptian Journal of Internal Medicine 2021 33:29
  23. Prediabetes is considered a major risk factor for diabetes mellitus (DM), leading to microvascular and cardiovascular disorders. Myocardial performance index (MPI) is a non-invasive Doppler method for the dete...

    Authors: Hossam Eldin M. Mahmoud, Mohamed Alsenbesy, Gehad Osama Fawzy Sayed, Abdulla Eliaw Mohamed Ali and Ahlam M. Sabra
    Citation: The Egyptian Journal of Internal Medicine 2021 33:28
  24. The prevalence of diabetes mellitus is on rising trend in developing countries like India. In type 2 diabetes patients, albuminuria has been shown to predict development of dysfunction in other organ systems s...

    Authors: Jiteshri Mehta, Varsha Y. Godbole, Kedar G. Mehta and A. Lalithambigai
    Citation: The Egyptian Journal of Internal Medicine 2021 33:27
  25. Heart failure (HF) is a major health problem. Cardiac and renal diseases interact in a complex bidirectional manner in both acute and chronic settings. Renal dysfunction in the setting of heart failure, termed...

    Authors: Ahmed Aly Obiedallah, Ashraf Anwar E. L. Shazly, Noura Gamal Nasr and Essam M. Abdel Aziz
    Citation: The Egyptian Journal of Internal Medicine 2021 33:25
  26. Metabolic syndrome (MetS) and thyroid dysfunction have a degree of close association, and each of them affects the other. Due to the associated cardiovascular events, MetS has increased morbidity and mortality...

    Authors: Gehad Abd El-Shaker Abd El-Hay, Salah Abdelazim Argoon and Naglaa Mohamed M. A. Mousa
    Citation: The Egyptian Journal of Internal Medicine 2021 33:24
  27. Dual left anterior descending (LAD) coronary artery is a rare congenital anomaly. To date, eleven variants of dual LAD have been described with three published reports of type X dual LAD. Here, we describe a n...

    Authors: Anish Bhargav, Parminder S. Otaal and Manphool K. Singhal
    Citation: The Egyptian Journal of Internal Medicine 2021 33:22
  28. Melanosis coli is a benign condition characterized by deposition of lipofuscin in colonic mucosa due to long-term laxative use.

    Authors: Anoop K V
    Citation: The Egyptian Journal of Internal Medicine 2021 33:23
  29. Sixty percent of Crohn’s disease (CD) patients require intestinal resection, and 20% of ulcerative colitis (UC) patients undergo proctocolectomy for medically refractory disease. Scarcity of literature about p...

    Authors: Khaled Hamdy Abd El Megeed, Shereen Abou Bakr Saleh, Ahmed Elkattary Mohamed and Christina Alphonse Anwar
    Citation: The Egyptian Journal of Internal Medicine 2021 33:19
  30. Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders (FGIDs). There is good evidence that microbiota plays a predominant role in the IBS pathophysiology. The aim of...

    Authors: Iman Mohamed Fawzy, Eman Mohamed ElGindy, Omar Abdel-Samie and Heba Aly
    Citation: The Egyptian Journal of Internal Medicine 2021 33:20
  31. Pruritus is a common and often distressing symptom in patients with chronic kidney disease. Though the pathogenesis of uremic pruritus remains poorly understood, systemic inflammation has presented itself as o...

    Authors: Sahar Mahmoud Shawky, Reeham Abdel Aziz Abdel Hamid and Lina Essam Khedr
    Citation: The Egyptian Journal of Internal Medicine 2021 33:17
  32. Hydroxychloroquine (HCQ) is an antimalarial drug, recently used in COVID-19 treatment. Also it is considered over many years the cornerstone in treating systemic lupus erythematosus (SLE) in adults and childre...

    Authors: Mohammed Salah Eldin Abdelbaky, Tarek Ahmad El Mamoun, Fatma Ibrahim Mabrouk and Rasha Mohamad Hassan
    Citation: The Egyptian Journal of Internal Medicine 2021 33:18
  33. Very few studies have investigated the role of PTX3 and PVT1 genetic polymorphisms and their association in the progression of diabetic kidney diseases. Diabetic kidney disease (DKD) is a prominent reason of end-...

    Authors: Sindhu Varghese and Gowtham Kumar Subburaj
    Citation: The Egyptian Journal of Internal Medicine 2021 33:21
  34. Contrast-induced nephropathy (CIN) is a serious complication with primary percutaneous coronary intervention (PPCI). We aimed to study the different predictors of CIN and determine the cutoff point of contrast...

    Authors: Mohamed Abdel-Ghany, Ghada Morsy and Yehia Taha Kishk
    Citation: The Egyptian Journal of Internal Medicine 2021 33:16
  35. The occurrence of bleeding gastrointestinal angioectasia in elderly patients with degenerative calcific aortic stenosis is one of the most challenging clinical scenarios. A number of studies have shown that th...

    Authors: Nelson Musilanga, Zhou Hongli and Cai Hongyu
    Citation: The Egyptian Journal of Internal Medicine 2021 33:15
  36. Delirium is a common geriatric problem associated with poor outcomes. Subsyndromal delirium (SSD) is characterized by the presence of certain symptoms of delirium yet, not satisfying the definition of full-blo...

    Authors: Maha Hosam El-Din Ibrahim, Manal Elmasry, Fady Nagy and Ahmed Abdelghani
    Citation: The Egyptian Journal of Internal Medicine 2021 33:14
  37. Reactive arthritis had been reported to occur after various vaccinations, including the tetanus toxoid vaccine; here, we report a case of ankylosing arthropathy suggested to be a complication of missed neglect...

    Authors: Mohamed A. Mahran, Ahmed A. Khalifa, Mohamed Eslam Elsherif and Omar Refai
    Citation: The Egyptian Journal of Internal Medicine 2021 33:13
  38. Behçet’s disease (BD) is also referred to as vascular BD when it frequently involves the heart and vessels. This study aimed to describe the cardiovascular manifestations in patients with BD and its correlatio...

    Authors: Nashwa Aly Morshedy, Dalia Fayez Mohammed, Fatma Mohammed Badr and Mohammed Abd El monem Teama
    Citation: The Egyptian Journal of Internal Medicine 2021 33:12
  39. Autoimmunity is used to cause by impairment of adaptive immunity alone, whereas autoinflammatory was originally defined as a consequence of unregulated innate immunity. So, the pathogenetic mechanisms of autoi...

    Authors: Emad M. El-Shebiny, Enas S. Zahran, Sabry A. Shoeib and Eman S. Habib
    Citation: The Egyptian Journal of Internal Medicine 2021 33:11
  40. Although the frequent respiratory affection in COVID-19, it is well established that it could be presented with a wide variation of gastrointestinal symptoms; however, it is the effect on the pancreas remains ...

    Authors: Mohamed-Naguib Wifi, Ahmed Nabil, Abeer Awad and Reham Eltatawy
    Citation: The Egyptian Journal of Internal Medicine 2021 33:10
  41. Poor glycaemic control is associated with a greater risk of development of heart failure in diabetic patients. We aimed to study the prevalence of left ventricular (LV) systolic and diastolic dysfunction in as...

    Authors: K. M. Hassan Ayman, A. Abdallah Mahmoud, A. Abdel-Mageed Eman, Sayed Marwa, M. Soliman Mona and T. Kishk Yehia
    Citation: The Egyptian Journal of Internal Medicine 2021 33:8
  42. Matrix metalloproteinase 9 (MMP-9) is an important inflammatory marker in diabetic nephropathy. Many studies assessed the association between MMP-9 gene polymorphism and different microvascular complications o...

    Authors: Kholoud Shalaby, Rania Bahriz, Nancy Mahsoub, Mohammed M. El-Arman and Ghada El-Said
    Citation: The Egyptian Journal of Internal Medicine 2021 33:7
  43. Hepatitis D virus (HDV) is highly pathogenic, and clinical studies revealed that HDV infection aggravates the natural history of the underlying hepatitis B virus (HBV) infection by progression to cirrhosis tha...

    Authors: Babajide B. Ajayi, Semsari Latbone, Iman U. Igwegbe, Ibrahim M. Kida, Babagana W. Goni, Oyebode O. Samuel, Joshua S. Dawurung, Hamidu M. Ibrahim, Ballah A. Danue, Idris Nasir Abdullahi and Bamidele S. Oderinde
    Citation: The Egyptian Journal of Internal Medicine 2021 33:5
  44. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Asmaa Gameel, Monir Bahgat, Seham Seif, Maha Habeeb, Mohammed Abd El-Ghany and Ahmed Youssef Altonbary
    Citation: The Egyptian Journal of Internal Medicine 2021 33:4

    The original article was published in The Egyptian Journal of Internal Medicine 2020 32:29

  45. This single-center randomized open-label clinical trial evaluates the effectiveness of doxycycline as a combination therapy for active rheumatoid arthritis (RA) with methotrexate (MTX).

    Authors: Eman M. Ibrahem, Salwa S. El-gendi, Amal A. Mahmoud, Sherif M. Abdel-Aal and Hanan Sharaf El-Deen Mohammed
    Citation: The Egyptian Journal of Internal Medicine 2021 33:3