- Case report
- Open access
- Published:
Hodgkin’s lymphoma presenting as autoimmune hemolytic anemia
The Egyptian Journal of Internal Medicine volume 29, pages 144–146 (2017)
Abstract
Hodgkin’s lymphoma is a B-cell neoplasm, which usually presents with painless lymphadenopathy. Its presentation with autoimmune hemolytic anemia (AIHA) is rare, although the association of AIHA with other lymphoproliferative disorders is well known. Here, we report a case of a patient with warm AIHA who presented in a critical condition to hospital and was diagnosed with HL.
References
Lanzkowsky P, editor. Manual of pediatrics hematology and oncology. 5th ed. New York, NY, USA: Elsevier; 2011.
Zanella A, Barcellini W. Treatment of autoimmune hemolytic anemias. Haematologica 2014; 99:1547–1554.
Michel M. Warm autoimmune hemolytic anemia:advances in pathophysiology and treatment. Presse Med 2014; 43(Pt 2):e97–e104.
Sokol RJ, Booker DJ, Stamps R. Erythrocyte autoantibodies, autoimmune haemolysis, and carcinoma. J Clin Pathol 1994; 47:340–343.
Bowdler AJ, Glick IW. Autoimmune hemolytic anaemia as the herald case of Hodgkin’s disease. Ann Intern Med 1966; 65:671–677.
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. In: Bosman FT, Jaffe ES, Lakhani SR, Ohgaki H, editors. World Health Organization Classification of Tumours. Lyon, France: IARC; 2008.
Feng Q, Zak D, Daya R. Autoimmune hemolytic anemia and classical Hodgkin lymphoma: a case report and literature review. Clin Adv Hematol Oncol 2012; 10:270–276.
Farrell K, Jarrett RF. The molecular pathogenesis of Hodgkin lymphoma. Histopathology 2011; 58:15–25.
Portis T, Dyck P, Longnecker R. Epstein-Barr virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma. Blood 2003; 102: 4166–4178.
Sallah S, Sigounas G, Vos P, Wan JY, Nguyen NP. Autoimmune hemolytic anemia in patients with non-Hodgkin’s lymphoma: characteristics and significance. Ann Oncol 2000; 11:1571–1577.
Ansell SM. Hodgkin lymphoma: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol 2016; 91:434–442.
Author information
Authors and Affiliations
Additional information
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Fatima, S., Siddiqui, W.A. & Alshehri, A. Hodgkin’s lymphoma presenting as autoimmune hemolytic anemia. Egypt J Intern Med 29, 144–146 (2017). https://doi.org/10.4103/ejim.ejim_15_17
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.4103/ejim.ejim_15_17