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Table 3 Comparison of radiographic and laboratory results between control and interventional arm

From: Effect of sustained virological response after direct-acting antivirals on liver fibrosis in patients with chronic HCV infection

 

Control arm (untreated cases)

Intervention arm (treated cases)

Test of significance

Fibroscan

 1

27.0 (15.0–73.0)

21.6 (8.9–75.0)

P=0.167

 2

21.3 (12.5–175.0)

16.8 (2.9–68.3)

P=0.07

 3

17.40 (10.3–27.0)

14.3 (2.9–56.0)

P=0.111

Test of significance between pre and post treatment

P1=0.05

P2=0.005*

P3=0.001*

P1=0.001*

P2=0.001*

P3=0.001*

 

FIB-4

 1

2.76 (0.93–9.030

2.38 (0.82–20.68)

P=0.511

 2

2.01 (0.58–8.74)

2.289 (0.58–16.39)

P=0.949

 3

2.10 (0.74–6.89)

2.065 (0.58–17.64)

P=0.956

Test of significance between pre and post treatment

P1=0.156

P2=0.019*

P3=0.221

P1=0.003*

P2=0.002*

P3=0.383

 

ALT

 1

32.0 (15.0–88.0)

27.0 (2.0–78.0)

P=0.08

 2

28.0 (15.0–59.0)

26.0 (10.0–128.0)

P=0.272

 3

28.0 (18.0–43.00

24.0 (8.0–86.0)

P=0.059

Test of significance between pre and post treatment

P1=0.271

P2=0.362

P3=0.969

P1=0.507

P2=0.009*

P3=0.026*

 

AST

 1

38 (17–94)

34 (11–85)

P=0.233

 2

32 (17–79)

28 (11–92)

P=0.143

 3

28.5 (20–45)

27 (7–96)

P=0.690

Test of significance between pre and post treatment

P1=0.300

P2=0.064

P3=0.02*

P1=0.019*

P2<0.001*

P3=0.003*

 

Platelets

 1

147 (57–259)

145 (33–343)

P=0.954

 2

154 (61–355)

148 (30–374)

P=0.347

 3

146 (65–280)

145 (37–333)

P=0.639

Test of significance between pre and post treatment

P1=0.101

P2=0.414

P3=0.014*

P1=0.275

P2=0.844

P3=0.021*

 

Bilirubin

 1

0.90 (0.3–2.0)

0.90 (0.30–2.50

P=0.734

 2

0.80 (0.5–1.4)

0.90 (0.3–5.0)

P=0.539

 3

0.85 (0.7–2.5)

0.90 (0.3–5.0)

P=0.701

Test of significance between pre and post treatment

P1=0.798

P2=0.306

P3=0.107

P1=0.726

P2=0.169

P3=0.061

 

Albumin

 1

3.93±0.53

4.16±0.39

P=0.04*

 2

4.19±0.48

4.08±0.49

P=0.408

 3

4.09±0.33

4.05±0.39

P=0.718

Test of significance between pre and post treatment

P1=0.133

P2=0.606

P3=0.123

P1=0.096

P2=0.007*

P3=0.365

 

EGD1

 OVs

0

50 (4.0)

P=0.645

 PHG

0

30 (2.4)

 

 Both

10 (6.7)

60 (4.8)

 

 Free

0

30 (2.4)

 

EGD2

 OVs

0

10 (0.8)

P=0.133

 PHG

10 (6.7)

60 (4.8)

 

 Both

10 (6.7)

0 (0.0)

 

 Free

0

0 (0.0)

 

EGD3

 PHG

20 (13.3)

40 (3.2)

P=0.125

Test of significance between pre and post treatment

P1=0.317

P2=1.0

P3=0.317

P1=0.180

P2=1.0

P3=1.0

 
  1. Used tests: Friedman test, repeated measures ANOVA test with post hoc Tukey test, Wilcoxon signed rank test, and Stewart Maxwell test
  2. Parameters described as mean±SD, median (range) (interquartile range) %1: percent of improvement between pre and post 1 follow-up, %2; percent of improvement between pre and post 2, %3: percent of improvement between post 1 and post 2
  3. *Statistically significant