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Table 2 Radiographic and laboratory results pre and post treatment among studied cases

From: Effect of sustained virological response after direct-acting antivirals on liver fibrosis in patients with chronic HCV infection

 

Pre

Post 1

Post 2

Overall significance

1 vs 2

1 vs 3

2 vs 3

Percent of improvement

Fibroscan

22.30 (8.9–75.0)

17.05 (2.9–75.0)

15.1 (2.9–56.0)

p<0.001*

p<0.001*

p<0.001*

p<0.001*

%1=22.7

%2=38.9

%3=20.92

FIB-4

2.41 (0.82–20.68)

2.19 (0.58–19.36)

2.06 (0.58–17.64)

p<0.001*

p=0.001*

p<0.001*

p=0.22

%1=16.8

%2=17.5

%3=0.84

ALT

28.0 (2.0–88.0)

26.5 (10.0–128.0)

24.0 (8.0–86.0)

p=0.257

p=0.313

p=0.005*

p=0.032*

%1=5.4

%2=12.2

%3=7.2

AST

34.0 (11.0–94.0)

28.0 (11.0–92.0)

28.0 (7.0–96.0)

p<0.001*

p=0.009*

p<0.001*

p<0.001*

%1=12.3

%2=19.04

%3=7.7

Platelet

145.0 (33.0–343.0)

148.5 (30.0–374.0)

145.0 (37.0–333.0)

p=0.175

p=0.117

p=0.653

p=0.002*

%1=4.4

%2=1.06

%3=3.2

Hb

13.0±1.46 (9.3–17.1)

13.11±1.33 (9.5–16.0)

13.17±1.17 (10.0–17.1)

p=0.131

p=0.14

p=0.163

p=0.926

%1=0.8

%2=1.3

%3=0.46

WBCS

5.75 (1.6–15.0)

5.77 (2.44–13.0)

6.0 (2.6–13.0)

p=0.398

p=0.127

p=0.125

p=0.333

%1=4.1

%2=5.6

%3=1.3

Bilirubin

0.90 (0.3–2.5)

0.89 (0.30–5.0)

0.90 (0.3–5.0)

p=0.01*

p=0.769

p=0.102

p=0.024*

%1=5.59

%2=7.4

%3=1.7

Albumin

4.135±0.41 (3.0–5.0)

4.09±0.48 (2.5–5.5)

4.05±0.38 (2.8–5.4)

p=0.002*

p=0.174

p=0.005*

p=0.06

%1=1.1

%2=2.1

%3=0.98

Creatinine

0.9 (0.21–1.6)

1.0 (0.4–2.2)

1.0 (0.6–1.4)

p=0.003*

p=0.02*

p<0.001*

p=0.195

%1=5.0

%2=6.7

%3=1.6

Alkaline phosphatase

116.0 (106–146)

93.5 (65.0–245.0)

127.5 (111.0–145.0)

p=0.001*

p=0.02*

p=0.001*

p=0.01*

%1=1.3

%2=4.1

%3=2.82

EGD

n=18

N=9

N=6

p=0.717

p=0.102

p=0.564

p=0.317

 

 OVs

5 (27.8)

1 (11.1)

0 (0.0)

     

 PHG

3 (16.7)

7 (77.8)

6 (100.0)

 Both

7 (38.9)

1 (11.1)

0 (0.0)

 Free

3 (16.7)

0 (0.0)

0 (0.0)

  1. Used tests: Friedman test, repeated measures ANOVA test with post hoc Tukey test, Wilcoxon signed rank test, and Stewart Maxwell test. Parameters described as mean±SD, median (range) (interquartile range), number and percentage %1: percent of improvement between pre and post 1 follow-up, %2: percent of improvement between pre and post 2, %3: percent of improvement between post 1 and post 2