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Nonendoscopic predictors of large esophageal varices

The Egyptian Journal of Internal Medicine volume 24, pages 97–99 (2012)Cite this article

Abstract

Background

There is a particular need for noninvasive predictors of esophageal varices (EV) that might help reduce medical, social, and economic costs. Our study aimed at studying the noninvasive predictors of EV.

Patients and methods

A total of 100 live cirrhotic patients with compensated liver functions were subjected to full clinical, laboratory, and imaging investigations.

Results

A total of 55% of the studied groups showed EV; 39% showed high-grade EV (grades III, IV, and V). Platelet count and platelet count/splenic diameter ratio have the highest accuracy and specificity for predicting EV, whereas platelet count/splenic diameter ratio has the highest predictive accuracy for the presence of large EV.

Conclusion

The platelet count/splenic diameter ratio can predict the presence of EV and large-sized EV.

References

  1. Madoura R, Mulcahy HE, Willner I, et al. Prediction of esophageal varices in patients with cirrhosis. J clin Gastroenterol 2002; 34:81–85.

    Article  Google Scholar 

  2. Sharma SK, Aggarwal R. Prediction of large esophageal varices in patients with cirrhosis of the liver using clinical, laboratory and imaging parameters. J Gastroenterol Hepatol 2007; 22:1909–1915.

    Article  Google Scholar 

  3. Ng FH, Wong SY, Loo CK, et al. Prediction of oesophagogastric varices in patients with liver cirrhosis. J Gastroenterol Hepatol 1999; 14:785–790.

    Article  CAS  Google Scholar 

  4. Pilette C, Oberti F, Aube C, et al. Non-invasive diagnosis of esophageal varices in chronic liver diseases. J Hepatol 1999; 31:867–873.

    Article  CAS  Google Scholar 

  5. Zaman A, Becker T, Lapidus J, et al. Risk factors for the presence of varices in cirrhotic patients without a history of variceal hemorrhage. Arch Intern Med 2001; 161:2564–2570.

    Article  CAS  Google Scholar 

  6. Zaman A, Hapke R, Flora K, et al. Factors predicting the presence of esophageal or gastric varices in patients with advanced liver disease. Am J Gastroenterol 1999; 94:3292–3296.

    Article  CAS  Google Scholar 

  7. Schepis F, Camma C, Niceforo D, et al. Which patients with cirrhosis should undergo endoscopic screening for esophageal varices detection? Hepatology 2001; 33:333–338.

    Article  CAS  Google Scholar 

  8. Giannini E, Botta F, Borro P, et al. Platelet count/spleen diameter ratio: proposal and validation of a non-invasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis. Gut 2003; 52: 1200–1205.

    Article  CAS  Google Scholar 

  9. Bressler B, Pinto R, El-Ashry D, et al. Which patients with primary biliary cirrhosis or primary sclerosing cholangitis should undergo endoscopic screening for oesophageal varices detection. Gut 2005; 54:407–410.

    Article  CAS  Google Scholar 

  10. Agha A, Anwar E, Bashir K, et al. External validation of the platelet count/ spleen diameter ratio for the diagnosis of esophageal varices in hepatitis C virus-related cirrhosis. Dig Dis Sci 2009; 54:654–660.

    Article  Google Scholar 

  11. Sen S, Griffiths WJ. Non-invasive prediction of oesophageal varices in cirrhosis. World J Gastroenterol 2008; 14:2454–2455.

    Article  Google Scholar 

  12. Peck-Radosavlijevic M, Zacherl J, Meng YG, et al. Is inadequate thrombo-poeitin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 1997; 27:127–131.

    Article  Google Scholar 

  13. Toghill P, Green S, Ferguson R. Platelets dynamics in liver disease with special reference to the role of the spleen. J Clin Pathol 1977; 30:367–371.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Internal Medicine Department, Faculty of Medicine, Cairo University, 11562, Cairo, Egypt

    Ahmed A. ElNaggar (MD), Mohamed S. Gomaa & May M. Fawzy

Authors
  1. Ahmed A. ElNaggar
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  2. Mohamed S. Gomaa
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  3. May M. Fawzy
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Corresponding author

Correspondence to Ahmed A. ElNaggar.

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ElNaggar, A.A., Gomaa, M.S. & Fawzy, M.M. Nonendoscopic predictors of large esophageal varices. Egypt J Intern Med 24, 97–99 (2012). https://doi.org/10.7123/01.EJIM.0000422605.92412.30

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  • DOI: https://doi.org/10.7123/01.EJIM.0000422605.92412.30

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