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The Egyptian Journal of Internal Medicine
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Mean platelet volume as a risk factor in pregnant diabetic women

The Egyptian Journal of Internal Medicine volume 24, pages 32–36 (2012)Cite this article

Abstract

Background

Diabetes is an established risk factor for cardiovascular disease (CVD); therefore, the subset of women with gestational diabetes mellitus (GDM) who develop type 2 diabetes mellitus is at an increased risk for developing CVD in the future.

Objectives

To assess the platelet count and mean platelet volume (MPV) of pregnant women with GDM and gestational impaired glucose tolerance (GIGT) to determine whether GDM and GIGT are risk factors for future development of CVD.

Patients and methods

A 50 g oral glucose load (OGL) was administered to all participants (400 pregnant women), and routine hematologic parameters and MPV were studied at 24–28 gestational weeks using a Beckman/Coulter MAXM Hematology Analyzer. When a plasma glucose level of at least 140 mg/dl was measured after administering OGL, a 100 g 3-h oral glucose tolerance test was performed. Of these women, 296 (74%) had normal oral glucose tolerance, 48 (12%) had GIGT, and 65 (14%) had GDM. The mean platelet counts were higher in the normal OGL group than in the GIGT group, and higher in the GIGT group than in the GDM group, with no statistically significant differences among the three groups. However, MPV was significantly higher in the GDM group than in the normal glucose level group (Po0.05). Also, women with high MPV values had lower platelet counts.

Results

A significant difference was observed for MPV values between the GDM and normal OGL groups.

Conclusion

Presence of a high MPV in cases of GDM could indicate an increased risk for current and future thrombotic complications.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Sohag University, Sohag, Egypt

    Sayed M. Abel-Rahman

  2. Department of Internal Medicine, Minia University, P.O. Box 61661, 7th, Ahmed Orabi St., Minia City, Minia, Egypt

    Essam S. Badawy MD

  3. Department of Obstetric and Gynecology, Zagazig University, Zagazig, Egypt

    Ahmad A. Amer

  4. Department of Hematology & Clinical Pathology, Ain-Shams University, Cairo, Egypt

    Dalal Fekry

Authors
  1. Sayed M. Abel-Rahman
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  2. Essam S. Badawy MD
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  3. Ahmad A. Amer
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  4. Dalal Fekry
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Corresponding author

Correspondence to Essam S. Badawy MD.

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Abel-Rahman, S.M., Badawy, E.S., Amer, A.A. et al. Mean platelet volume as a risk factor in pregnant diabetic women. Egypt J Intern Med 24, 32–36 (2012). https://doi.org/10.7123/01.EJIM.0000419581.67334.75

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  • DOI: https://doi.org/10.7123/01.EJIM.0000419581.67334.75

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