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Advances in the management of type 2 diabetes mellitus


  1. Turner R, Cull C, Holman R. United Kingdom prospective diabetes study 17:a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus. Ann Intern Med 1996; 124 (1 II):136–145.

  2. Kannel WB, McGee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease:The Framingham Study. Diabetes Care 1979; 2:120–126.

    Article  CAS  Google Scholar 

  3. UK prospective diabetes study 6. Complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors. Diabetes Res 1990; 13:1–11.

    Google Scholar 

  4. Wright A, Burden ACF, Paisey RB, Cull CA, Holman RR. Sulfonylurea inadequacy:efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.. Prospective Diabetes Study (UKPDS 57). Diabetes Care 2002; 25:330–336.

    CAS  PubMed  Google Scholar 

  5. Bagg W, Plank LD, Gamble G, Drury PL, Sharpe N, Braatvedt GD. The effects of intensive glycaemic control on body composition in patients with type 2 diabetes. Diabetes Obes Metab 2001; 3:410–416.

    Article  CAS  Google Scholar 

  6. Mäkimattila S, Nikkilä K, Yki Järvinen H. Causes of weight gain during insulin therapy with and without metformin in patients with type II diabetes mellitus. Diabetologia 1999; 42:406–412.

    Article  Google Scholar 

  7. Groop LC. Sulfonylureas in NIDDM. Diabetes Care 1992; 15:737–754.

    Article  CAS  Google Scholar 

  8. Tessier D, Dawson K, Tetrault JP, Bravo G, Meneilly GS. Glibenclamide vs gliclazide in type 2 diabetes of the elderly. Diabetic Med 1994; 11:974–980.

    Article  CAS  Google Scholar 

  9. Bailey CJ, Turner RC. Metformin. N Engl J Med 1996; 334:574–579.

    Article  CAS  Google Scholar 

  10. Defronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 1995; 333:541–549.

    Article  CAS  Google Scholar 

  11. Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006; CD002967.

  12. Yki Järvinen H. Thiazolidinediones. N Engl J Med 2004; 351:1106–1118.

    Article  Google Scholar 

  13. Goldberg RB, Kendall DM, Deeg MA, Buse JB, Zagar AJ, Pinaire JA, et al. A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care 2005; 28:1547–1554.

    Article  CAS  Google Scholar 

  14. Van de Laar FA, Lucassen PL, Akkermans RP, Van de Lisdonk EH, Rutten GE, Van Weel C. Alpha-glucosidase inhibitors for type 2 diabetes mellitus. Cochrane Database Syst Rev 2005; CD003639.

  15. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acar-bose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance:The STOP-NIDDM trial. JAMA 2003; 290:486–494.

    Article  CAS  Google Scholar 

  16. Drucker DJ, Sherman SI, Gorelick FS, Bergenstal RM, Sherwin RS, Buse JB. Incretin-based therapies for the treatment of type 2 diabetes:evaluation of the risks and benefits. Diabetes Care 2010; 33:428–433.

    Article  CAS  Google Scholar 

  17. Schmitz O, Brock B, Rungby J. Amylin agonists:a novel approach in the treatment of diabetes. Diabetes 2004; 53 (Suppl 3):S233–S238.

  18. Hollander PA, Levy P, Fineman MS, Maggs DG, Shen LZ, Strobel SA, et al. Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes:a 1-year randomized controlled trial. Diabetes Care 2003; 26:784–790.

    Article  CAS  Google Scholar 

  19. Gerich J, Raskin P, Jean Louis L, Purkayastha D, Baron MA. PRESERVE-β:two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin. Diabetes Care 2005; 28:2093–2099.

    Article  CAS  Google Scholar 

  20. Rosenstock J, Hassman DR, Madder RD, Brazinsky SA, Farrell J, Khutor-yansky N, et al. Repaglinide versus nateglinide monotherapy:a randomized, multicenter study. Diabetes Care 2004; 27:1265–1270.

    Article  CAS  Google Scholar 

  21. Kristen JS, Frandsen KB, Bayer T, Muller PG. Compared with repaglinide sulfonylurea treatment in type 2 diabetes is associated with a 2.5-fold increase in symptomatic hypoglycemia with blood glucose levels < 45 mg/dl. Diabetes 2000; 49 (Suppl 1):A131.

  22. Khan MA, St. Peter JV, Xue JL. A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone. Diabetes Care 2002; 25:708–711.

    CAS  PubMed  Google Scholar 

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Correspondence to Nariman Moustafa.

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Moustafa, N. Advances in the management of type 2 diabetes mellitus. Egypt J Intern Med 24, 1–3 (2012).

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