Skip to main content
  • Original article
  • Open access
  • Published:

Sonographic evaluation of enthesopathy in rheumatoid arthritis patients

Abstract

Background

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. It affects mainly the synovial membranes of the small joints. However, it may also have extra-articular manifestations. Enthesopathy may occur as one of the extra-articular manifestations of RA and is not clinically detected. Ultrasound (US) is a relatively new tool for the detection of enthesopathy.

Aim

The aim of this study was to assess the presence and distribution of enthesopathy in RA patients using US.

Patients and methods

Twenty-nine consecutive patients with RA and 14 age-matched healthy controls were included in this study. All RA patients met the 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for RA. Six entheses sites were evaluated using gray scale and Doppler US with a linear transducer and were scored using the Madrid Sonography Enthesitis Index (MASEI).

Results

US detected the presence of enthesopathy in patients with RA. There was a statistically significant difference in the enthesopathy score of plantar aponeurosis insertion and Achilles tendon insertion. The total enthesopathy score was statistically significant in patients with RA versus controls.

Conclusion

US entheseal abnormalities are present in a high percentage of RA patients. US enthesopathy is not associated with disease activity in RA patients.

References

  1. Mahajan TD, Mikuls TR. Recent advances in the treatment of rheumatoid arthritis. Curr Opin Rheumatol 2018; 30:231–237.

    Article  CAS  Google Scholar 

  2. Littlejohn EA, Monrad SU. Early diagnosis and treatment of rheumatoid arthritis. Prim Care 2018; 45:237–255.

    Article  Google Scholar 

  3. Sacks JJ, Luo YH, Helmick CG. Prevalence of specific types of arthritis and other rheumatic conditions in the ambulatory health care system in the United States, 2001–2005. Arthritis Care Res 2010; 62:460–464.

    Article  Google Scholar 

  4. Turesson C. Extra-articular rheumatoid arthritis. Curr Opin Rheumatol 2013; 25:360–366.

    Article  CAS  Google Scholar 

  5. Terslev L, Naredo E, Iagnocco A, Balint PV, Wakefield RJ, Aegerter P, et al. Defining enthesitis in spondyloarthritis by ultrasound: results of a Delphi process and of a reliability reading exercise. Arthritis Care Res 2014; 66:741–748.

    Article  CAS  Google Scholar 

  6. De Miguel E, Cobo T, Muñoz-Fernández S, Naredo E, Usón J, Acebes JC, et al. Validity of enthesis ultrasound assessment in spondyloarthropathy. Ann Rheum Dis 2009; 68:169–174.

    Article  Google Scholar 

  7. Gandjbakhch F, Conaghan PG, Ejbjerg B, Haavardsholm EA, Foltz V, Brown AK, et al. Synovitis and osteitis are very frequent in rheumatoid arthritis clinical remission: results from an MRI study of 294 patients in clinical remission or low disease activity state. J Rheumatol 2011; 38:2039–2044.

    Article  Google Scholar 

  8. D’Agostino MA, Aegerter P, Bechara K, Salliot C, Judet O, Chimenti MS, et al. How to diagnose spondyloarthritis early? Accuracy of peripheral enthesitis detection by power Doppler ultrasonography. Ann Rheum Dis 2011; 70:1433–1440.

    PubMed  Google Scholar 

  9. Kay J, Upchurch KS. ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology 2012; 51:vi5–vi9.

    Article  Google Scholar 

  10. Prevoo M, van’T Hof MA, Kuper H, van Leeuwen M, van De Putte L, van Riel P. Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995; 38:44–48.

    Article  CAS  Google Scholar 

  11. Genc H, Cakit BD, Tuncbilek I, Erdem HR. Ultrasonographic evaluation of tendons and enthesal sites in rheumatoid arthritis: comparison with ankylosing spondylitis and healthy subjects. Clin Rheumatol 2005; 24:272–277.

    Article  Google Scholar 

  12. Scutellari PN, Orzincolo C. Rheumatoid arthritis: sequences. Eur J Radiol 1998; 27:S31–S38.

    Article  Google Scholar 

  13. Bicer A. Musculoskeletal findings in Behcet’s disease. Patholog Res Int 2012; 2012:653806.

    PubMed  Google Scholar 

  14. Michelsen B, Diamantopoulos AP, Soldal DM, Hammer HB, Kavanaugh A, Haugeberg G. Achilles enthesitis defined by ultrasound is not associated with clinical enthesitis in patients with psoriatic arthritis. RMD Open 2017; 3: e000486.

    Article  Google Scholar 

  15. Balint P, Kane D, Wilson H, McInnes I, Sturrock R. Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy. Ann Rheum Dis 2002; 61:905–910.

    Article  CAS  Google Scholar 

  16. Kamel M, Eid H, Mansour R. Ultrasound detection of knee patellar enthesitis: a comparison with magnetic resonance imaging. Ann Rheum Dis 2004; 63:213–214.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Samar Tharwat MD.

Additional information

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tharwat, S., Nassar, M.K., Enein, A. et al. Sonographic evaluation of enthesopathy in rheumatoid arthritis patients. Egypt J Intern Med 31, 715–719 (2019). https://doi.org/10.4103/ejim.ejim_9_19

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/ejim.ejim_9_19

Keywords