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Usefulness of serum osteopontin level as a noninvasive parameter of portal hypertension

The Egyptian Journal of Internal Medicine volume 31, pages 502–507 (2019)Cite this article

Abstract

Background

Osteopontin (OPN) is a multifunctional protein that is physiologically expressed in the kidney and bone. Plasma OPN levels were shown to predict liver fibrosis in various chronic liver diseases and could be related to the degree of portal hypertension. The aim of the study is to investigate the usefulness of OPN as a noninvasive biomarker of portal hypertension.

Patients and methods

A case–control study including 90 (45 patients with confirmed liver cirrhosis and 45 normal healthy individuals) patients were enrolled in the study. Laboratory investigations with abdominal ultrasound and duplex of the portal system were carried out for all patients. OPN was measured using the enzyme-linked immunosorbent assay in the plasma.

Results

Compared with controls, the plasma levels of OPN in cirrhotic patients were significantly high (P<0.001). Also, plasma levels of OPN were significantly high in patients with portal hypertension (P<0.001). The cutoff value of OPN to detect the presence of portal hypertension is 1.65 ng/ml with sensitivity and specificity of 80 and 95.6%, respectively).

Conclusion

Serum OPN is a good noninvasive parameter to detect portal hypertension.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

    Ayman M. Fouad, Nagwa Ramadan Ahmed Hussein MD Degree of Internal Medicine & Mohammed A. Ismael

  2. Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

    Iman A. E. Shaheen

  3. Division of Gastroenterology and Hepatology, Faculty of Medicine, Cairo University, 9 Shannan Street, Mostafa Abd Razek, Abdeen, Giza, 11613, Egypt

    Nagwa Ramadan Ahmed Hussein MD Degree of Internal Medicine

Authors
  1. Ayman M. Fouad
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  2. Nagwa Ramadan Ahmed Hussein MD Degree of Internal Medicine
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  3. Iman A. E. Shaheen
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  4. Mohammed A. Ismael
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Corresponding author

Correspondence to Nagwa Ramadan Ahmed Hussein MD Degree of Internal Medicine.

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Fouad, A.M., Hussein, N.R.A., Shaheen, I.A.E. et al. Usefulness of serum osteopontin level as a noninvasive parameter of portal hypertension. Egypt J Intern Med 31, 502–507 (2019). https://doi.org/10.4103/ejim.ejim_91_19

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  • DOI: https://doi.org/10.4103/ejim.ejim_91_19

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