Skip to main content
The Egyptian Journal of Internal Medicine
Download PDF
  • Original article
  • Open access
  • Published:

The prevalence of Helicobacter pylori cagA (+ve) among patients with gastric cancer: an Egyptian study

The Egyptian Journal of Internal Medicine volume 31, pages 522–528 (2019)Cite this article

Abstract

Introduction and aims

Gastric cancer is currently the second most common cause of cancer-related death in the world and the fifth most common cancer and the fourth leading cause of cancer-related death in Europe. It has been evident for more than the past 20 years that Helicobacter pylori is involved in the development of gastric adenocarcinoma. The cagA gene of H. pylori is the main virulence factor that leads to the development of gastric adenocarcinoma through the derangement of cellular architecture and signaling. The objective of our work is to study the prevalence of cagA among patients with gastric cancer.

Patients and methods

This descriptive study was done on 60 patients with gastric cancer underwent serum anti-H. pylori IgM and anti-cagA IgG assessment, computed tomography, upper endoscopy, and biopsy taking, and if needed, computed tomography-guided biopsy, followed by histopathological examination.

Results

A total of 34 (56.67%) patients were cagA +ve and 26 (43.33%) patients were cagA -ve, with no statistically significant difference regarding sex or age.

Conclusion

H. pylori cagA plays a significant role in development of gastric cancer, so we recommend not only H. pylori screening but also cagA virulence strain.

References

  1. National Cancer Institute of Egypt website 2014. Web Page: https://seer.cancer.gov/statfacts/html/stomach.html

  2. Khatoon J, Rai RP, Prasad KN. Role of Helicobacter pylori in gastric cancer: updates. World J Gastrointest Oncol 2016; 8:147.

    Article  Google Scholar 

  3. Ansari S, Yamaoka Y. Survival of Helicobacter pylori in gastric acidic territory. Helicobacter 2017; 22:e12386.

    Article  Google Scholar 

  4. Hoy B, Löwer M, Weydig C, et al. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO Rep 2010; 11:798–804.

    Article  CAS  Google Scholar 

  5. Al-Eraky DM, Helmy OM, Ragab YM, et al. Prevalence of CagA and antimicrobial sensitivity of H. pylori isolates of patients with gastric cancer in Egypt. Infect Agent Cancer 2018; 13:24.

    Article  Google Scholar 

  6. Liu J, Liu H, Zhang T, et al. Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer. Sci Rep 2014; 4:4143.

    Article  Google Scholar 

  7. Meine GC, Rota C, Dietz J, et al. Relationship between caga-positive Helicobacter pylori infection and risk of gastric cancer: a case control study in Porto Alegre, RS, Brazil. Arq Gastroenterol 2011; 48:41–45.

    Article  Google Scholar 

  8. Güdücüoğlu H, Berktaş M, Bozkurt H, et al. Evaluation of Western Blot method for the detection of antibodies to Helicobacter pylori antigens in patients with gastric carcinoma and cases with epigastric complaints. Mikrobiyol Bul 2010; 44:21–28.

    PubMed  Google Scholar 

  9. Erzin Y, Koksal V, Altun S, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia. 2006.

  10. Said Essa A, Alaa Eldeen Nouh M, Mohammed Ghaniam N, et al. Prevalence of cagA in relation to clinical presentation of Helicobacter pylori infection in Egypt. Scand J Infect Dis 2008; 40:730–733.

    Article  CAS  Google Scholar 

  11. Suzuki, Seiji Shiota, Osamu Matsunari, et al. Serum Helicobacter pylori CagA antibody as a biomarker for gastric cancer in east-Asian countries. Future Microbiol 2011; 5:1885–1893.

    Google Scholar 

  12. Cai H, Ye F, Michel A, et al. Helicobacter pylori blood biomarker for gastric cancer risk in East Asia. Int J Epidemiol 2016; 45:774–781.

    Article  Google Scholar 

  13. Peleteiro B, Cavaleiro-Pinto M, Barros R, et al. Is cardia cancer aetiologically different from distal stomach cancer? Eur J Cancer Prev 2011; 20:96–101.

    Article  Google Scholar 

  14. Filipec Kanizaj T, Katicić M, Presecki V, et al. Serum antibodies positivity to 12 Helicobacter pylori virulence antigens in patients with benign or malignant gastroduodenal diseases–cross-sectional study. Croat Med J 2009; 50:124–132.

    Article  Google Scholar 

  15. Formichella L, Romberg L, Meyer H, et al. Validation of a novel immunoline assay for patient stratification according to virulence of the infecting Helicobacter pylori strain and eradication status. J Immunol Res 2017; 2017:8394593.

    Article  Google Scholar 

  16. Ren JS, Qiao YL. Helicobacter pylori infection and gastric cardia cancer: a nested case-control study. Zhonghua Zhong Liu Za Zhi 2008; 30: 428–431.

    PubMed  Google Scholar 

  17. Cavaleiro-Pinto M, Peleteiro B, Lunet N, et al. Helicobacter pylori infection and gastric cardia cancer: systematic review and meta-analysis. Cancer Causes Control 2011; 22:375–387.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology, Cairo University, 26, 1st Touristic Area, 6th October City, Cairo, 1256, Egypt

    Ahmed N. El Mazny (MD Internal Medicine), Tarek Hishmat & Ahmed Hussein

  2. Department of Clinical Pathology, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt

    Doaa Gaith

Authors
  1. Ahmed N. El Mazny
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tarek Hishmat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ahmed Hussein
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Doaa Gaith
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ahmed N. El Mazny.

Additional information

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

El Mazny, A.N., Hishmat, T., Hussein, A. et al. The prevalence of Helicobacter pylori cagA (+ve) among patients with gastric cancer: an Egyptian study. Egypt J Intern Med 31, 522–528 (2019). https://doi.org/10.4103/ejim.ejim_66_19

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/ejim.ejim_66_19

Keywords