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Seroprevalence of acute hepatitis C virus infection among mortuary workers and ambulance drivers in Plateau State, Nigeria

Abstract

Nigeria is one of the countries highly endemic for viral hepatitis. However, data on the prevalence of hepatitis C virus (HCV) infection among mortuary workers and ambulance drivers has not been documented. Hence, this study sought to determine the seroprevalence of HCV among mortuary workers and ambulance drivers in Plateau State, North Central Nigeria. Between December 2015 and February 2016, a total of 80 blood samples were collected from mortuary workers and ambulance drivers with the view to test for HCV antibody using rapid immunochromatographic test (ICT) and enzyme-linked immunosorbent assay for anti-HCV immunoglobulin M. Three milliliter of blood was collected from each patient and the serum was separated out and used for the screening. A self-administered questionnaire was used to access the patients’ sociodemographic variables. Of the 80 samples analyzed, five (6.3%) were positive for HCV using the rapid immunochromatographic assay, while two (2.5%) were positive for anti-HCV immunoglobulin M. There was no statistical association between seroprevalence of HCV with age and sex of patients. However, the seroprevalence of HCV was significantly associated with contact with blood, number of sexual partners, use of gloves, and history of sexually transmitted infections (P<0.05). The HCV seroprevalence of 2.5% among mortuary workers and ambulance drivers was relatively low; however, this suggests that the patients are at-risk group for occupational infection due to HCV.

References

  1. Nasir IA, Yakubu S, Mustapha JO. Epidemiology and synergistic hepatopathology of malaria and hepatitis C virus coinfection. Virology (Auckl) 2017; 8:1–4.

    Google Scholar 

  2. Center for Disease Control. National hepatitis C prevention strategy. Hepatitis C infection in the United State viral hepatitis C. Atlanta, USA: National Center for Infectious Disease, Center for Disease Control; 2001. pp. 1–5.

    Google Scholar 

  3. Sharma SD. Hepatitis C virus: molecular biology and current therapeutic options. Indian J Med Res 2010; 131:17–34.

    CAS  PubMed  Google Scholar 

  4. World Health Organization. Hepatitis C fact sheet no. 164. 2017. Available at: http://www.who.Int/mediacentre/Fact Sheets/fs164/en/. [Accessed 26 June 2017].

  5. CDC. Viral hepatitis. Hepatitis C FAQs for the public. 2016. Available at: http://www.cdc.gov/hepatitis/hcv/cfaq.htm. [Accessed 26 June 2017].

  6. Cacoub P, Comarmond C, Domont F, Savey L, Desbois AC, Saadoun D. Extrahepatic manifestations of chronic hepatitis C virus infection. Ther Adv Infect Dis 2016; 3:3–14.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Chen J, Zhao Y, Zhang C, Chen H, Feng J, Chi X, et al. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Res 2014; 24:1050–1066.

    Article  CAS  Google Scholar 

  8. Lavanchy D, Gavinio P. Hepatitis C. Can J Gastroenterol 2000; 14 (Suppl B):67B–76B.

    Article  Google Scholar 

  9. Ohto H, Terazawa S, Sasaki N, Hino K, Ishiwata C, Kako M, et al. Transmission of hepatitis C virus from mothers to infants. N Engl J Med 1994; 330:744–750.

    Article  CAS  Google Scholar 

  10. Scott JD, Gretch DR. Molecular diagnostics of hepatitis C virus infection: a systematic review. JAMA 1997; 297:724–732.

    Article  Google Scholar 

  11. Pawlotsky JM. Use and interpretation of hepatitis C virus diagnostic assays. Clin Liver Dis 2013; 7:127–137.

    Article  Google Scholar 

  12. Alao O, Okwori E, Araoye M. The sero-prevalence of hepatitis C virus (HCV) infection among prospective blood donors in a Nigerian Tertiary Health Institution. Int J Epidemiol 2008; 7:1–6.

    Google Scholar 

  13. Halim NK, Ajayi OI. Risk Factors and sero- prevalence of hepatitis C antibody in blood donors in Nigeria. East Afr Med J 2000; 77:410–412.

    CAS  PubMed  Google Scholar 

  14. Koate BB, Buseri FI, Jeremiah ZA. Seroprevalance of hepatitis C virus among blood donors in Rivers State, Nigeria. Transfus Med 2005; 15:449–451.

    Article  CAS  Google Scholar 

  15. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet infect Dis 2005; 5:558–567.

    Article  Google Scholar 

  16. McQuillan GM, Alter MJ, Moye LA, Lambert SB, Morgohs HS. Prevalence based serology study of hepatitis C virus infection in the United State. J Hepatol 1997; 204:267–270.

    Google Scholar 

  17. Layden JE, Phillips R, Opare-Sem O, Akere A, Salako BL, Nelson K, et al. Hepatitis C in sub-Saharan Africa: urgent need for attention. Open Forum Infect Dis 2014; 1:1–3.

    Article  Google Scholar 

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Correspondence to Idris-Abdullahi Nasir MSc.

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Uruku, J.M., Dangana, A., Nasir, IA. et al. Seroprevalence of acute hepatitis C virus infection among mortuary workers and ambulance drivers in Plateau State, Nigeria. Egypt J Intern Med 30, 35–39 (2018). https://doi.org/10.4103/ejim.ejim_66_17

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