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The Egyptian Journal of Internal Medicine
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Serum selenium level in acute myocardial infarction

The Egyptian Journal of Internal Medicine volume 30, pages 28–34 (2018)Cite this article

Abstract

Introduction

Although remarkable developments have been made in the management of cardiovascular disease, myocardial infarction (MI) remains the most common cause of death worldwide. MI is an acute condition of myocardial cell death that occurs as a result of imbalance between the coronary blood supply and myocardial requirements. Lipid peroxidation and excessive production of reactive oxygen species (ROS), such as superoxide anions (O2•-) and hydrogen peroxide, play a major role in the mechanism of MI. ROS directly damage the cell membrane and cause cell necrosis. However, ROS also stimulate signal transfer to upregulate inflammatory cytokines, for example, tumor necrosis factor-α in the ischemic area and the neighboring myocardium.

Aim

The aims of this article were: (a) to determine serum selenium (Se) and the cut-off value in acute MI patients and the correlation between serum Se and other cardiac biomarkers such as troponin, creatine kinase (CK), creatine kinase myocardial brand (CK-MB), C-reactive protein, and lipogram; and (b) to determine the most predictor risk factor of MI.

Materials and methods

The study was carried out on 120 individuals (60 patients and 60 controls). The patients presented to the Internal Medicine Department and Coronary Care Unit at Assiut University Hospital. The healthy controls were selected and matched for age and sex, and only those who were found to be in good health and free from any signs of chronic diseases or disorders were included.

Results

The main finding of this analysis that there is a statistical difference between patients and controls in serum Se as the mean Se level in patients was 80.3±20.5 and in controls it was 97.2±14.0 and P value of less than 0.001, Thus, serum Se is significantly low in MI patients. Also, there was no statistical difference in serum Se in terms of sex, smoking, accompanying diseases (diabetes or hypertension), or type of infarction.

Conclusion

This study supports a significant association between deficient serum Se concentration with cut-off value of up to 84ng/ml and MI. Strikingly, the most predictor of MI is serum Se, followed by total cholesterol, diabetes mellitus, low-density lipoprotein, and hypertension.

References

  1. Stadtman TC. Selenoproteins – tracing the role of a trace element in protein function. PLoS Biol 2005; 3:e421.

    Google Scholar 

  2. Bermano G, Nicol F, Dyer JA, Sunde RA, Beckett GJ, Arthur JR, Hesketh JE. Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochem J 1995; 311:425–430.

    Article  CAS  Google Scholar 

  3. Joseph J, Loscalzo J. Selenistasis: epistatic effects of selenium on cardiovascular phenotype. Nutrients 2013; 5:340–358.

    Article  CAS  Google Scholar 

  4. Benstoem C, Goetzenich A, Kraemer S, Borosch S, Manzanares W, Hardy G, Stoppe C. Selenium and its supplementation in cardiovascular disease – What do we know? Nutrients 2015; 7:3094–3118.

    Article  CAS  Google Scholar 

  5. Panicker S, Swathy SS, John F, Madambath I. Impact of selenium on NFkappaB translocation in isoproterenol-induced myocardial infarction in rats. Biol Trace Elem Res 2010; 138:202–211.

    Article  CAS  Google Scholar 

  6. Afridi HI, Kazi TG, Kazi N, Sirajuddin, Kandhro GA, Baig JA, et al. Chromium and manganese levels in biological samples of Pakistani myocardial infarction patients at different stages as related to controls. Biol Trace Elem Res 2011; 142:259–273.

    Article  CAS  Google Scholar 

  7. Altekin E, Coker C, Sisman AR, Onvural B, Kuralay F, Kirimli O. The relationship between trace elements and cardiac markers in acute coronary syndromes. J Trace Elem Med Biol 2005; 18:235–242.

    Article  CAS  Google Scholar 

  8. Weber KT, Weglicki WB, Simpson RU. Macroand micronutrient dyshomeostasis in the adverse structural remodeling of myocardium. Cardiovasc Res 2009; 81:500–508.

    Article  CAS  Google Scholar 

  9. Alimohamady R, Aliarabi H, Bahari A, Dezfoulian AH. Influence of different amounts and sources of selenium supplementation on performance, some blood parameters, and nutrient digestibility in lambs. Biol Trace Elem Res 2013; 154:45–54.

    Article  CAS  Google Scholar 

  10. Thiry C, Schneider YJ, Pussemier L, De Temmerman L, Ruttens A. Selenium bioaccessibility and bioavailability in Se-enriched food supplements. Biol Trace Elem Res 2013; 152:152–160.

    Article  CAS  Google Scholar 

  11. Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, et al. Myocardial infarction accelerates atherosclerosis. Nature 2012; 487:325–329.

    Article  CAS  Google Scholar 

  12. Li F, Gao1 J, Zhang B. Association between deficient selenium levels and myocardial infarction: a meta-analysis. Int J Clin Exp Med 2016; 9:6086–6609.

    CAS  Google Scholar 

  13. Nomoto A, Higuchi Y, Kobiki Y, Ogawa A. Synthesis of selenium compounds by free radical addition based on visible-light-activated sese bond cleavage. Mini Rev Med Chem 2013; 13:814–823.

    Article  CAS  Google Scholar 

  14. Christensen K, Werner M, Malecki K. Serum selenium and lipid levels association observed in the national health and nutrition examination survey (NHANES); 2011–2012. Environ Res 2015; 140:76–84.

    Article  CAS  Google Scholar 

  15. Navas-Acien A, Bleys J, Guallar E. Selenium intake and cardiovascular risk: What is new? Curr Opin Lipidol 2008; 19:43–49.

    Article  CAS  Google Scholar 

  16. Ahrens I, Ellwanger C, Smith BK, Bassler N, Chen YC, Neudorfer I, et al. Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes. J Leukoc Biol 2008; 83:1388–1395.

    Article  CAS  Google Scholar 

  17. Forman HJ, Torres M. Reactive oxygen species and cell signaling: Respiratory burst in macrophage signaling. Am J Respir Crit Care Med 2002; 166:S4–S8.

    Article  Google Scholar 

  18. Stranges S, Laclustra M, Ji C, Cappuccio FP, Navas-Acien A, Ordovas JM, et al. Higher selenium status is associated with adverse blood lipid profile in British adults. J Nutr 2010; 140:81–87.

    Article  CAS  Google Scholar 

  19. Nawrot TS, Staessen JA, Roels HA, Den Hond E, Thijs L, Fagard RH, et al. Blood pressure and blood selenium: a cross-sectional and longitudinal population study. Eur Heart J 2007; 28:628–633.

    Article  CAS  Google Scholar 

  20. Berthold HK, Michalke B, Krone W, Guallar E, Gouni-Berthold I. Influence of serum selenium concentrations on hypertension: the lipid analytic cologne cross-sectional study. J Hypertens 2012; 30:1328–1335.

    Article  CAS  Google Scholar 

  21. Zhuravlyova L, Filonenko M. The correlation between serum selenium level and cardiac biomarkers in patients with acute myocardial infarction. Arch Cardiovasc Dis Suppl 2016; 8:12.

    Google Scholar 

  22. Ghashut RA, Mc Millan DC, Kinsella J, Vasilaki AT, Talwar D, Duncan A. The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin. Clin Nutr 2016; 2:381–387.

    Article  Google Scholar 

  23. Radchenko EN, Nizov AA, Ivanova AY, Sidorova YS. The content of selen in blood plasma in patients with acute Q-wave myocardial infarction. Vopr Pitan 2015; 84:64–69.

    CAS  PubMed  Google Scholar 

  24. Chen A, Li G, Liu Y. Association between copper levels and myocardial infarction: a meta-analysis. Inhal Toxicol 2015; 27:237–246.

    Article  CAS  Google Scholar 

  25. Afridi HI, Kazi TG, Talpur FN, Kazi A, Arain SS, Arain SA, et al. Interaction between selenium and mercury in biological samples of Pakistani myocardial infarction patients at different stages as related to controls. Biol Trace Elem Res 2014; 158:143–151.

    Article  CAS  Google Scholar 

  26. Kutil B, Ostadal P, Vejvoda J, Kukacka J, Cepova J, Alan D, et al. Alteration in serum selenium levels and their relation to troponin I in acute myocardial infarction. Mol Cell Biochem 2010; 345:23–27.

    Article  CAS  Google Scholar 

  27. Xun P, Liu K, Morris JS, Daviglus ML, He K. Longitudinal association between toenail selenium levels and measures of subclinical atherosclerosis: The CARDIA trace element study. Atherosclerosis 2010; 210:662–667.

    Article  CAS  Google Scholar 

  28. Li S, Zheng MQ, Rozanski GJ. Glutathione homeostasis in ventricular myocytes from rat hearts with chronic myocardial infarction. Exp Physiol 2009; 94:815–824.

    Article  CAS  Google Scholar 

  29. Tang NP, Wang LS, Yang L, Gu HJ, Sun QM, Cong RH, et al. Genetic variant in glutathione peroxidase 1 gene is associated with an increased risk of coronary artery disease in a Chinese population. Clin Chim Acta 2008; 395:89–93.

    Article  CAS  Google Scholar 

  30. Hassanzadeh M, Faridhosseini R, Mahini M, Faridhosseini F, Ranjbar A. Serum levels of TNF-, IL-6, and selenium in patients with acute and chronic coronary artery disease. Iran J Immunol 2006; 3:142–145.

    PubMed  Google Scholar 

  31. Wells EM, Navas-Acien A, Apelberg BJ, Herbstman JB. Association of selenium and copper with lipids in umbilical cord blood. J Dev Orig Health Dis 2014; 281:281–287.

    Article  Google Scholar 

  32. Flores-Mateo G, Navas-Acien A, Pastor-Barriuso R, Guallar E. Selenium and coronary heart disease: a meta-analysis. Am J Clin Nutr 2006; 84:762–773.

    Article  CAS  Google Scholar 

  33. Alanne M, Kristiansson K, Auro K, Silander K, Kuulasmaa K, Peltonen L, et al. Variation in the selenoprotein s gene locus is associated with coronary heart disease and ischemic stroke in two independent finnish cohorts. Hum Genet 2007; 122:355–365.

    Article  CAS  Google Scholar 

  34. Lubos E, Sinning CR, Schnabel RB, Wild PS, Zeller T, Rupprecht HJ, et al. Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study. Atherosclerosis 2010; 209:271–277.

    Article  CAS  Google Scholar 

  35. Navarro-Alarcon M, Cabrera-Vique C. Selenium in food and the human body: a review. Sci Total Environ 2008; 400:115–141.

    Article  CAS  Google Scholar 

  36. Wen H, Carignan J. Reviews on atmospheric selenium: emissions, speciation and fate. Atmospheric Environ 2007; 41:7151–7165.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Assiut University Hospital, 71111, Assiut, Egypt

    Abdallah I. Ali Kelani, Hanan S. El-Deen Mohammed, Mona M. Soliman & Mai A. Fathi BSc

  2. Department of Cardiology, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt

    Marwa Sayed

  3. Department of Biochemistry, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt

    Hala M. El-Badre

Authors
  1. Abdallah I. Ali Kelani
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  2. Hanan S. El-Deen Mohammed
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  6. Mai A. Fathi BSc
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Correspondence to Mai A. Fathi BSc.

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Ali Kelani, A.I., El-Deen Mohammed, H.S., Soliman, M.M. et al. Serum selenium level in acute myocardial infarction. Egypt J Intern Med 30, 28–34 (2018). https://doi.org/10.4103/ejim.ejim_63_17

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  • DOI: https://doi.org/10.4103/ejim.ejim_63_17

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