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Genetic variants of two-pore calcium channel 2 rs1551305 and its association with type 2 diabetes risk

The Egyptian Journal of Internal Medicine volume 31, pages 8–13 (2019)Cite this article

Abstract

Context

The prevalence of diabetes is highest in the Eastern Mediterranean Region, with Egypt leading the region (11% for both sexes) and lowest in the European Region (7% for both sexes). Genome-wide association studies of single-nucleotide polymorphisms (SNPs) have identified a number of variants that are associated with β-cell function and insulin resistance. Two-pore calcium channel 2 (TPCN2) localizes to the lysosome and is a likely receptor for the calcium-mobilizing agent nicotinic acid adenine dinucleotide phosphate. Several studies have indicated that nicotinic acid adenine dinucleotide phosphate may play a role in the insulin signaling of β-cells.

Aim

of the study The aim of this study was to investigate the association between TPCN2 rs1551305 SNPs and the development of type 2 diabetes.

Patients and methods

A sample of 158 Egyptian participants was divided into two groups. Group one included 79 type 2 diabetic patients and group two included 79 healthy controls. TPCN2 rs1551305 SNPs were determined by the real-time PCR technique.

Results

A significant increase in the frequency of G/G genotype in diabetic patients was found. A/A genotype was significantly more frequent in the control group (P=0.001). G allele was also significantly higher in diabetic patients (P=0.008). The G/G genotype showed a 21.37-fold increase in the risk of developing diabetes mellitus.

Conclusion

The previous findings suggest that TPCN2 rs1551305 SNP is associated with the risk of type 2 diabetes development.

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Authors and Affiliations

  1. Department of Internal Medicine, Cairo University, Cairo, Egypt

    Kareem Essam MD

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  1. Kareem Essam MD
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Correspondence to Kareem Essam MD.

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Essam, K. Genetic variants of two-pore calcium channel 2 rs1551305 and its association with type 2 diabetes risk. Egypt J Intern Med 31, 8–13 (2019). https://doi.org/10.4103/ejim.ejim_58_18

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