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The Egyptian Journal of Internal Medicine
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Does brain natriuretic peptide have a significant diagnostic value in subclinical peripheral atrial disease type 2 diabetic patients?

The Egyptian Journal of Internal Medicine volume 29, pages 189–195 (2017)Cite this article

Abstract

Background

Peripheral arterial disease (PAD) is a serious complication of diabetes mellitus (DM); it is also correlated with increase in the morbidity and mortality in diabetics owing to cardiovascular disease. Ankle–brachial index (ABI) is an established method to detect PAD.

Patients and methods

This is a cross-sectional study to detect brain natriuretic peptide (BNP) level in patient with type-2 DM with PAD using ABI.

Results

This study revealed 11 patients diagnosed with low ABI. Patients with low ABI showed statistical significance regarding mean age (P=0.038), duration of DM (P=0.004), concentration of glycated hemoglobin (P=0.044), BNP (P=0.013), and microalbuminurea (P=0.007). Moreover, patients with low ABI were significantly associated with nephropathy (P=0.001) and retinopathy (P=0.007). BNP at cutoff value of 360 pg/ml had sensitivity and specificity of 27.27 and 95.9, respectively. The BNP level was negatively correlated with the ABI (r= –0.183, P=0.162). BNP showed statistical significance with fasting blood sugar, postprandial glucose, nephropathy, retinopathy, and albumin/creatinine ratio in urine.

Conclusion

BNP is a potential and a promising biomarker for PAD screening in patients with type-2 DM.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Helwan Faculty of Medicine University, 11795, Cairo, Egypt

    Eman M. Fahmy (MD)

  2. Department of Vascular Surgery, Helwan Faculty of Medicine University, Cairo, Egypt

    Ahmed M. El Mahdi

  3. Department of Critical Care Medicine, Helwan Faculty of Medicine University, Cairo, Egypt

    Mohamed A. Monem Saeed

  4. Department of Medical Biochemistry, Assiut Faculty of Medicine, Assiut University, Assiut, Egypt

    Marwa A. Gaber

Authors
  1. Eman M. Fahmy
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  2. Ahmed M. El Mahdi
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  3. Marwa A. Gaber
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  4. Mohamed A. Monem Saeed
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Correspondence to Eman M. Fahmy.

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Fahmy, E.M., El Mahdi, A.M., Gaber, M.A. et al. Does brain natriuretic peptide have a significant diagnostic value in subclinical peripheral atrial disease type 2 diabetic patients?. Egypt J Intern Med 29, 189–195 (2017). https://doi.org/10.4103/ejim.ejim_58_17

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  • DOI: https://doi.org/10.4103/ejim.ejim_58_17

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