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Serum β-CrossLaps as a predictor for osteoporosis in postmenopausal women with early diabetic nephropathy

The Egyptian Journal of Internal Medicine volume 31, pages 52–56 (2019)Cite this article

Abstract

Background

Osteoporosis is a progressive bone disease with an increased risk of fracture.

Objective

To estimate bone turnover through an early marker, β-CrossLaps (β-CTx), in postmenopausal women with type 2 diabetes mellitus (DM) and early diabetic nephropathy (DN).

Patients and methods

A case–control study comprised 80 Egyptian postmenopausal nonsmoker women: 26 women without DM (group 1) as a control group, 28 women had type 2 DM without DN (group 2), and 26 woman were type 2 DM with early DN (group 3). All demographic and clinical data were collected. Laboratory tests including serum calcium, phosphorus, alkaline phosphatase (ALP), bone ALP, β-CTx, glycated hemoglobin, microalbuminuria, serum creatinine, and blood sugar levels were estimated.

Results

Regarding bone minerals, there was a significant lower serum level of calcium and phosphorus in group 3 compared with groups 1 and 2 (P=0.029 and <0.0001, respectively). Groups 2 and 3 had significantly lower serum levels of total ALP (P=0.011 and 0.006, respectively) and bone ALP (with lowest level in group 3) (P<0.0001) compared with group 1. Groups 2 and 3 had significantly higher serum levels of β-CTx (with highest level in group 3) compared with group 1 (P=0.016 and 0.003, respectively). Dual-energy X-ray absorptiometry scan revealed a significant elevation in osteoporosis percent in group 3 (63.4%) in comparison with group 1 (26.9%) (P=0.001), whereas osteopenia percent was significantly higher in group 2 (P=0.004) compared with group 3.

Conclusion

In diabetic postmenopausal women, serum β-CTx and microalbuminuria are potentially useful tools for assessing bone resorption state.

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Authors and Affiliations

  1. Faculty of Medicine, Mansoura University, Mansoura, Dakahlyiah, 35516, Egypt

    Ashraf Mohamed MD (Assistant prof. of Internal Medicine)

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  1. Ashraf Mohamed MD
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Correspondence to Ashraf Mohamed MD.

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Mohamed, A. Serum β-CrossLaps as a predictor for osteoporosis in postmenopausal women with early diabetic nephropathy. Egypt J Intern Med 31, 52–56 (2019). https://doi.org/10.4103/ejim.ejim_53_18

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