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The Egyptian Journal of Internal Medicine
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Assessment of serum irisin level in thyroid disorder

The Egyptian Journal of Internal Medicine volume 30, pages 197–203 (2018)Cite this article

Abstract

Background

Irisin is a newly discovered myokin secreted by myocytes responsible for transmission of signals from muscles to other body tissues. Irisin improves systemic metabolism by increasing the energy expenditure. Owing to numerous similarities in action between irisin and thyroid hormones it seems imperative to explore these substances’ potential mutual influence on the body.

Objective

To estimate serum irisin concentration in patients with hypothyroid and hyperthyroid diseases, and to detect the relation of serum irisin in patients with thyroid disorders with creatine kinase (CK), a serum marker of muscle damage.

Patients and methods

The study comprised 30 hyperthyroid patients (group 1), 30 hypothyroid patients (group 2), and 30 normal persons (group 3). Irisin was measured using enzymelinked immunosorbent assay. Thyroid-stimulating hormone, triiodothyronine, and free thyroxine levels were measured using chemiluminescent microparticle immunoassay technology.

Results

Irisin hormone level significantly decreased in hypothyroid patients in comparison with hyperthyroid patients. Irisin hormone level increased in hyperthyroid patients in comparison with normal persons, whereas it decreased in hypothyroid patients in comparison with normal persons. CK level significantly decreased in hyperthyroid patients in comparison with hypothyroid patients. CK level significantly increased in hypothyroid patients in comparison with normal persons, whereas it significantly decreased in hyperthyroid patients in comparison with normal persons.

Conclusion

Obtained results suggest the influence of thermometabolic state on irisin level.

References

  1. Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 2012; 8:457–465.

    Article  CAS  Google Scholar 

  2. Timmons JA, Baar K, Davidsen PK, Atherton PJ. Is irisin a human exercise gene?. Nature 2012; 488:E9– E10.

    Article  CAS  Google Scholar 

  3. Boström P, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481:463–468.

    Article  Google Scholar 

  4. Lahesmaa M, Orava J, SchalinJäntti C, Soinio M, Hannukainen JC, Noponen T, et al. Hyperthyroidism increases brown fat metabolism in humans. J Clin Endocrinol Metab 2014; 99:E28–E35.

    Article  Google Scholar 

  5. Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, et al. Effects of obesity, diabetes and exercise on FNDC5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 2014; 592:1091–1107.

    Article  CAS  Google Scholar 

  6. Harper ME, Seifert EL. Thyroid hormone effects on mitochondrial energetics. Thyroid 2008; 18:145–156.

    Article  CAS  Google Scholar 

  7. Ruchala M, Zybek A, Szczepanek-Parulska E. Irisin – newly discovered adipomyokine and its association with thyroid function – preliminary study. Endocrine Abstracts 2014; 35:996.

    Google Scholar 

  8. McGrowder DA, Fraser YP, Gordon L, Crawford TV, Rawlins JM. Serum creatine kinase and lactate dehydrogenase activities in patients with thyroid disorders. Niger J Clin Pract 2011; 14:45–49.

    Article  Google Scholar 

  9. Prakash A, Lal AK, Negi KS. Serum creatine kinase activity in thyroid disorders. JK Sci 2007; 9:1.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Internal Medicine, Endocrinology and Metabolism, Ain Shams University Hospital, Cairo, 11566, Egypt

    Mohamed R. Halawa, Mona M. Abdelsalam, Bassem M. Mostafa MD & Amira G. Ahmed

Authors
  1. Mohamed R. Halawa
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  2. Mona M. Abdelsalam
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  3. Bassem M. Mostafa MD
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  4. Amira G. Ahmed
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Corresponding author

Correspondence to Bassem M. Mostafa MD.

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Halawa, M.R., Abdelsalam, M.M., Mostafa, B.M. et al. Assessment of serum irisin level in thyroid disorder. Egypt J Intern Med 30, 197–203 (2018). https://doi.org/10.4103/ejim.ejim_37_18

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  • DOI: https://doi.org/10.4103/ejim.ejim_37_18

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