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The Egyptian Journal of Internal Medicine
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Study of hepcidin level in patients with chronic kidney disease and its correlation with markers of iron status in Zagazig University Hospital

The Egyptian Journal of Internal Medicine volume 30, pages 284–288 (2018)Cite this article

Abstract

Context

Chronic kidney disease (CKD) including hemodialysis (HD) is considered an inflammatory state leading to hepcidin upregulation, which affects iron homeostasis.

Aims

The aim was to assess the serum level of hepcidin in CKD including HD patients and its correlation with markers of iron status.

Settings and design

The study was conducted in Zagazig University hospital.

Participants and methods

A prospective, case–control, comparative study was conducted on 66 participants, who were divided into control group, comprising 22 healthy participants; HD group, comprising 22 patients; and CKD group, comprising 22 patients from stages 2 to 4. All participants were evaluated for serum creatinine, complete blood count, estimated glomerular filtration rate by MDRD4 equation, serum iron, total iron-binding capacity, serum ferritin, transferrin saturation, C-reactive protein, and serum hepcidin level.

Statistical analysis

The study was analyzed using SPSS version 20. Description of the qualitative variables was done by frequency and percentage. Description of the quantitative variables was in the form of mean and SD. χ2 -Test, Student’s t-test, analysis of variance (F-test), and correlation analysis were used for analyzing the data.

Results

Serum level of hepcidin was increase by increase stages of CKD, and more increase in regular HD patients. There was high statistically significant positive correlation of hepcidin level with serum ferritin (P<0.001), serum iron (P<0.05) in CKD and negative correlation with Hb, eGFR (P<0.001), and it was not correlated with total iron binding capacity (TIBC) (P<0.48).

Conclusion

Serum hepcidin levels are a good biomarker for iron status in patients with HD and CKD. In addition, determination of hepcidin together with markers associated with iron metabolism improves the identification of patients with iron deficiency.

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Authors and Affiliations

  1. Department of Internal Medicine, Zagazig University Hospital, Zagazig, Egypt

    Nafesa M. Kamal MD & Magda Diab

  2. Department of Clinical Pathology, Faculty of Medicine, Zagazig University Hospital, Zagazig, Egypt

    Rania A. Khalil

Authors
  1. Nafesa M. Kamal MD
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  2. Magda Diab
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  3. Rania A. Khalil
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Correspondence to Nafesa M. Kamal MD.

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Kamal, N.M., Diab, M. & Khalil, R.A. Study of hepcidin level in patients with chronic kidney disease and its correlation with markers of iron status in Zagazig University Hospital. Egypt J Intern Med 30, 284–288 (2018). https://doi.org/10.4103/ejim.ejim_31_18

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  • DOI: https://doi.org/10.4103/ejim.ejim_31_18

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