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Type 1 diabetes mellitus and enterovirus linkage: search for associated etiopathology

The Egyptian Journal of Internal Medicine volume 29, pages 93–99 (2017)Cite this article

Abstract

Type 1 diabetes (T1D) is believed to have complex interplay between several enteroviruses (EVs) and host immune system disturbance induced or accelerated by viral pathogenesis. In the past two decades, there has been global upsurge in the incidence of childhood T1D, especially in those less than 5 years. Because of the ubiquity and persistence of EVs in human bowel and their tropism to pancreatic cells, they tend to express certain viral proteins that have propensity for genetic manipulation and activation of autoimmunity that could be potentially linked to T1D. In view of these, we present this review of existing literature in order to analyze the epidemiology and possible association between EV infections, host immune dysfunction, and development of autoimmunity or T1D with the view to encourage the investigation of EV infections and associated virus-induced islet cells autoimmunity and immunopathy in genetically predisposed children.

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Author information

Authors and Affiliations

  1. Department of Medical Microbiology and Parasitology, University of Ilorin, Ilorin, Egypt

    Idris Abdullahi Nasir MSc

  2. Department of Medical Laboratory Services, University of Abuja Teaching Hospital, PMB 228, Abuja, Gwagwalada, Egypt

    Idris Abdullahi Nasir MSc

  3. Department of Obstetric and Gyaenacology, University of Abuja Teaching Hospital, Gwagwalada, Egypt

    Maryam M. Zakari

  4. Department of Strategic Information and Research, Institute of Human Virology, Abuja, Egypt

    Nkechi Onukegbe Peters

  5. Department of Medical Laboratory Science, University of Calabar, Calabar, Egypt

    Anthony U. Emeribe

  6. Department of Immunology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria

    Halima A. Shuwa

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  1. Idris Abdullahi Nasir MSc
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  2. Anthony U. Emeribe
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  3. Halima A. Shuwa
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Correspondence to Idris Abdullahi Nasir MSc.

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Nasir, I.A., Emeribe, A.U., Shuwa, H.A. et al. Type 1 diabetes mellitus and enterovirus linkage: search for associated etiopathology. Egypt J Intern Med 29, 93–99 (2017). https://doi.org/10.4103/ejim.ejim_25_17

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