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The role of mean platelet volume in predicting severity and prognosis of liver cirrhosis in Egyptian patients

The Egyptian Journal of Internal Medicine volume 31, pages 261–265 (2019)Cite this article

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Abstract

Background and aims

Liver cirrhosis is a major public health problem in Egypt due to widespread infection of hepatitis C virus. Mean platelet volume (MPV) is a noninvasive, inexpensive parameter of complete blood count. In this study we aimed at evaluating the association between MPV and clinical features, complications, and severity of cirrhosis in Egyptian patients.

Patients and methods

One hundred and fourteen patients with cirrhosis of various grades of severity and various presentations were enrolled in our study. The patients were evaluated to assess the association between MPV values and cirrhosis parameters, model for end-stage liver disease score, and fibrosis (FIB4) score.

Results

The study demonstrates the positive correlation between MPV values and international normalized ratio, serum bilirubin, lower serum albumin in cirrhotic patients. Also, the MPV values were significantly higher in patients with more severe liver disease according to the model for end-stage liver disease (r=+0.424, P=0.008) and FIB4 scores (r=+0.353, P=0.03).

Conclusion

MPV can be used as an important inexpensive biomarker in cirrhotic patients for the degree of severity and prognosis of the disease.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Zagazig University Hospital, Zagazig, Egypt, 44519

    Mohamed S. Mohamed MD, Mohamed A. A. Bassiony & Ayman F. Elsayed Mohamed

Authors
  1. Mohamed S. Mohamed MD
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  2. Mohamed A. A. Bassiony
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  3. Ayman F. Elsayed Mohamed
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Correspondence to Mohamed S. Mohamed MD.

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Mohamed, M.S., Bassiony, M.A.A. & Elsayed Mohamed, A.F. The role of mean platelet volume in predicting severity and prognosis of liver cirrhosis in Egyptian patients. Egypt J Intern Med 31, 261–265 (2019). https://doi.org/10.4103/ejim.ejim_111_18

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  • DOI: https://doi.org/10.4103/ejim.ejim_111_18

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