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The Egyptian Journal of Internal Medicine
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Bile carcinoembryonic cell adhesion molecule 6 as a potential diagnostic tool for malignant biliary stenotic lesions

The Egyptian Journal of Internal Medicine volume 31, pages 544–549 (2019)Cite this article

Abstract

Aim

Validate the biliary carcinoembryonic antigen-related cell adhesion molecule 6 in differentiating malignant from benign biliary lesions.

Background

The nature of biliary stenosis needs to be diagnosed early and accurately to give the patient the best chance of therapy. Imaging techniques still lack the high accuracy for this purpose. Different biomarkers were postulated to increase the diagnostic accuracy, and of them, carcinoembryonic cell adhesion molecule 6 (CEAM6) in bile was investigated in this study.

Patients and methods

Forty-four patients with biliary stenosis were enrolled in this prospective study in Assiut University Hospital from 2017 to 2019. CEAM6 concentration in bile and serum was measured using human carcinoembryonic antigen-related cell adhesion molecule 6 ELISA kit from SinoGeneClon Biotech Co. Ltd, and CA19-9 concentration in serum was assessed by the ELISA kit for CA19-9 from USCN Life Science Inc.

Results

The area under the curve, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of bile CEAM6 for diagnosis of stricture type among the study population were 0.841, 83, 74, 77, 82, and 78.5%, respectively, at a cut-off value of 6.15 ng/ml. Multivariate analysis showed age, CEAM6, CA19-9, and alkaline phosphatase as good predictors of malignancy.

Conclusion

CEAM6 in bile could be a good diagnostic tool to detect the nature of biliary stenosis.

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Authors and Affiliations

  1. Department of Internal Medicine, Alrajhy Liver Hospital, Faculty of Medicine, Assiut university, Assiut, 71511, Egypt

    Mohamed Abd-Elhakim Mahdy MSc (Now MD Degree) & Lobna Abdel Wahid

  2. Department of Clinical Pathology, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt

    Alaa S. Abd-Elkader

  3. Department of General Surgery, Alrajhy Liver Hospital, Egypt

    Ramy A. Hassan

  4. Department of Internal Medicine, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt

    Hanan M. Ahmed

Authors
  1. Mohamed Abd-Elhakim Mahdy MSc
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  2. Lobna Abdel Wahid
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  3. Alaa S. Abd-Elkader
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  4. Ramy A. Hassan
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  5. Hanan M. Ahmed
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Correspondence to Mohamed Abd-Elhakim Mahdy MSc.

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Mahdy, M.AE., Wahid, L.A., Abd-Elkader, A.S. et al. Bile carcinoembryonic cell adhesion molecule 6 as a potential diagnostic tool for malignant biliary stenotic lesions. Egypt J Intern Med 31, 544–549 (2019). https://doi.org/10.4103/ejim.ejim_107_19

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  • DOI: https://doi.org/10.4103/ejim.ejim_107_19

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