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Urinary cyclophilin A in Egyptian patients with type 2 diabetes and diabetic nephropathy: correlation with urine albumin/creatinine ratio

The Egyptian Journal of Internal Medicine volume 31, pages 790–794 (2019)Cite this article

Abstract

Introduction

Albuminuria is commonly used to predict the onset and to follow the progression of diabetic nephropathy (DN), but it lacks both sensitivity and specificity in early stages.

Aim

We assessed urinary cyclophilin A (CypA) as a biomarker for the diagnosis of DN in Egyptian patients with type 2 diabetes.

Patients and methods

The study was conducted on 150 Egyptian participants aged 30–65 years; 125 (58 male individuals and 67 female individuals) patients with type 2 diabetes mellitus (diabetes duration>5 years) in different stages of DN and 25 age-matched and sex-matched healthy control participants comprised the study cohort. Estimated glomerular filtration rate and urine albumin/creatinine ratio (ACR) were assessed in all participants. Urinary CypA was measured in the morning specimen.

Results

Urinary CypA was significantly higher in patients with stage 2 DN, as compared with stage 1 patients (P=0.02) and the control group (P=0.017), with no significant change in urine ACR between stages 1 and 2 (P=0.809). Urinary CypA also showed a steady rise in DN stages 3, 4 and 5 (P<0.001). Urinary CypA had strong positive correlations with creatinine and urine ACR and a strong negative correlation with estimated glomerular filtration rate in patients with DN (P<0.001 for all).

Conclusion

We suggest that urinary CypA is a good biomarker for early detection of DN in patients with type 2 diabetes. It starts to rise before urine ACR. It also correlates well with the progression of DN. A larger study is needed to confirm its superiority over urine ACR in the early stages of DN.

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Authors and Affiliations

  1. Department of Internal Medicine, Cairo University, 99 El-Manial Street, Giza, Cairo, 11451, Egypt

    Aasem Saif FRCP, Eman Elsayed, Amr Shaker, Basma Zaghlol & Shrook Mousa

  2. Department of Clinical and Chemical Pathology, Cairo University, Giza, Egypt

    Tarek Ramzy

Authors
  1. Aasem Saif FRCP
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  2. Eman Elsayed
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  3. Amr Shaker
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  4. Tarek Ramzy
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  5. Basma Zaghlol
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  6. Shrook Mousa
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Corresponding author

Correspondence to Aasem Saif FRCP.

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Saif, A., Elsayed, E., Shaker, A. et al. Urinary cyclophilin A in Egyptian patients with type 2 diabetes and diabetic nephropathy: correlation with urine albumin/creatinine ratio. Egypt J Intern Med 31, 790–794 (2019). https://doi.org/10.4103/ejim.ejim_103_19

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  • DOI: https://doi.org/10.4103/ejim.ejim_103_19

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