- Case report
- Open Access
Spontaneous hemothorax: primary pleural epithelioid angiosarcoma
The Egyptian Journal of Internal Medicine volume 28, pages 170–173 (2016)
Spontaneous hemothorax is a rare condition seen in coagulation and vascular disorders. Uncommonly, malignant neoplasms may cause spontaneous hemothorax. Primary pleural epithelioid angiosarcomas (excluding the cases with pleuropulmonary or chest wall involvement) are extremely rare pleural tumors, which may be mistaken for mesothelioma or adenocarcinoma, and only 19 cases (one of them from India) have been reported in the English literature, to date. It commonly occurs in older men, has a nonspecific clinicoradiological presentation, and carries a poor prognosis with no survivors beyond a year of establishing the diagnosis. We report a case of primary pleural epithelioid angiosarcoma presenting as a life-threatening spontaneous hemothorax. We also present a brief literature review on pleural angiosarcoma.
Heffner JE. Non malignant pleural effusions. In: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, Senior RM, editors. Fishman’s pulmonary diseases and disorders. 5th ed. New York: McGraw Hill; 2015. pp. 1164–87.
Ali HA, Lippmann M, Mundathaje U, Khaleeq G. Spontaneous hemothorax: a comprehensive review. Chest 2008; 134:1056–1065.
Zhang S, Zheng Y, Liu W, Yu X. Primary epithelioid angiosarcoma of the pleura: a case report and review of literature. Int J Clin Exp Pathol 2015; 8:2153–2158.
Shah SP, Kooka DM, Palkar SD, Dave KM, Kamat SR. Angiosarcoma of heart and lungs. J Assoc Physicians India 1983; 31:385–387.
Jain G, Mukhopadhyay S, Kurien S, Yusuf J, Tyagi S, Jain R. Ruptured cardiac angiosarcoma with pulmonary metastases: a rare disease with a common (mis)diagnosis! Indian Heart J 2012; 64:603–606.
Jain A, Simon S, Elangovan I. 18F-fluoro-deoxyglucose positron emission tomography–computed tomography in initial assessment and diagnosis of right atrial angiosarcoma with widespread visceral metastases: a case report and review of literature. Indian J Nucl Med 2015; 30:51–54.
Krishnamurthy A, Nayak D, Ramshankar V, Majhi U. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in the detection of primary pulmonary angiosarcomas. Indian J Nucl Med 2015; 30:142–144.
Pramesh CS, Madur BP, Raina S, Desai SB, Mistry RC. Angiosarcoma of the pleura. Ann Thorac Cardiovasc Surg 2004; 10:187–190.
Varsano S, Edelstein E, Gendel B, Smorzik J. Bilateral and unilateral spontaneous massive hemothorax as a presenting manifestation of rare tumors. Respiration 2003; 70:214–218.
Moriya Y, Sugawara T, Arai M, Tsuda Y, Uchida K, Noguchi T, et al. Bilateral massive bloody pleurisy complicated by angiosarcoma. Intern Med 2007; 46:125–128.
Abu-Zaid A, Mohammed S. Primary pleural angiosarcoma in a 63-year-old gentleman. Case Rep Pulmonol 2013; 2013:974567.
Roh MS, Seo JY, Hong SH. Epithelioid angiosarcoma of the pleura: a case report. J Korean Med Sci 2001; 16:792–795.
Chen CY, Wu YC, Chou TY, Yang KY. Pleural angiosarcoma mimicking pleural haematoma. Interact Cardiovasc Thorac Surg 2013; 17:886–888.
Kao YC, Chow JM, Wang KM, Fang CL, Chu JS, Chen CL. Primary pleural angiosarcoma as a mimicker of mesothelioma: a case report. Diagn Pathol 2011; 6:130.
Baisi A, Raveglia F, Simone M, Cioffi U. Primary multifocal angiosarcoma of the pleura. Interact Cardiovasc Thorac Surg 2011; 12:1069–1070.
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work noncommercially, as long as the author is credited and the new creations are licensed under the identical terms
About this article
Cite this article
Panjwani, A., Singh, I., Parvataneni, N. et al. Spontaneous hemothorax: primary pleural epithelioid angiosarcoma. Egypt J Intern Med 28, 170–173 (2016). https://doi.org/10.4103/1110-7782.203298
- spontaneous hemothorax