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Assessment of severity of bronchial asthma by studying new markers: transforming growth factor-β1 and chitinase-3-like-1



The aim of this work was to look for non-invasive biomarkers that may enable us to assess asthma severity, as a surrogate for the invasive bronchial mucosa biopsy, by studying TGF-β1 and YKL-40.


TGF-β1 is used as biomarkers in the pathogenesis, prediction and follow up of asthma severity. YKL-40 has a role in airway inflammation; this relation suggests that YKL-40 and TGF-β1 can be used as biomarkers in the pathogenesis, prediction and follow-up of asthma severity.


Defective extracellular matrix (ECM) turnover characterizes airway remodeling. Transforming Growth Factor Beta-1 (TGF-β1) stimulate airway remodeling through activation of gene transcription via binding to specific subfamilies of cell transmembrane receptors.


The work was done on a 60 subject aged between 20–40 years with equal sex. Classified into three groups; 20 patients with mild asthma, 20 patients with severe asthma and 20 normal subjects were taken as controls. For all subjects chest X-ray, pulmonary functions tests, allergy skin prick test, eosinophilic count, total IgE, YKL-40 and TGF-β1 in serum were performed.


The results showed that serum TGF-β1 and serum YKL-40 between the three groups were highly significantly different (P<0.01) between the three groups in asthmatic patients compared with control group.


These variations were correlated positively with the severity of the disease indicating that their increased serum levels may be a biological characteristic of the disease exacerbation with a sentinel role in asthma.


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Correspondence to Farag Khalil MBBCH, MSc, MD.

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Lotfy, A.M., Khalil, F., Zidan, H. et al. Assessment of severity of bronchial asthma by studying new markers: transforming growth factor-β1 and chitinase-3-like-1. Egypt J Intern Med 28, 155–161 (2016).

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