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Study of the LMNA 1908 C/T gene polymorphism in type 2 diabetic Egyptians with vascular complications

The Egyptian Journal of Internal Medicine volume 27, pages 103–107 (2015)Cite this article

Abstract

Aims/introduction

Vascular complications are the main cause of morbidity and mortality in type 2 diabetic patients. Genetic susceptibility is associated with the evolution of diabetic complications. One such gene is the lamin A and C gene located on chromosome 1q21, a susceptibility locus for type 2 diabetes mellitus, and encodes nuclear lamins A and C. The LMNA 1908 C/T polymorphism has been reported to be associated with dyslipidemia, metabolic syndrome, and obesity, suggesting that this polymorphism increases the risk of atherosclerosis and vascular disease. The present study aims to elucidate the association between the LMNA 1908 C/T single nucleotide polymorphism and the prevalence of vascular complications in a sample of type 2 diabetic Egyptian patients.

Materials and methods

Genomic DNA from 47 type 2 diabetic patients with vascular complications and 20 control participants was analyzed for the LMNA 1908 C/T polymorphism using PCR- RFLP.

Results

Carriers of the LMNA 1908 T-allele showed a significantly higher prevalence in patients with diabetic nephropathy than carriers of the C-allele (P < 0.05). Multiple regression analysis showed that the LMNA 1908 T-allele tended to be independent risk factor for diabetic nephropathy (P = 0.012, odds ratio = 5.460).

Conclusion

The findings of this study suggest that the LMNA 1908 C/T single nucleotide polymorphism is associated with the development of diabetic nephropathy in Egyptian type 2 diabetic patients.

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Authors and Affiliations

  1. Departments of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt other The study was carried out in the Internal Medicine Clinics, Diabetes Clinic and Internal Medicine Hospital of Kasr El Aini Hospital, Faculty of Medicine, Kasr Al Aini Street, 11562, Cairo, Egypt

    Heba Mostafa, Manal Eldeeb, Ahmed Hamdy MD & Rasha M Abdel Samie

  2. Departments of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt other The study was carried out in the Internal Medicine Clinics, Diabetes Clinic and Internal Medicine Hospital of Kasr El Aini Hospital, Faculty of Medicine, Cairo, Egypt

    Badawy El-Kholy, Nahla Fawzy, Ahmed Eltaweel & Nahed M. Ibrahim

Authors
  1. Heba Mostafa
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  2. Manal Eldeeb
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  3. Ahmed Hamdy MD
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  4. Rasha M Abdel Samie
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  5. Badawy El-Kholy
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  6. Nahla Fawzy
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  7. Ahmed Eltaweel
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  8. Nahed M. Ibrahim
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Corresponding author

Correspondence to Ahmed Hamdy MD.

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Mostafa, H., Eldeeb, M., Hamdy, A. et al. Study of the LMNA 1908 C/T gene polymorphism in type 2 diabetic Egyptians with vascular complications. Egypt J Intern Med 27, 103–107 (2015). https://doi.org/10.4103/1110-7782.165440

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  • DOI: https://doi.org/10.4103/1110-7782.165440

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