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Late initiation of dialysis in diabetic Egyptian patients

Abstract

Introduction

The number of chronic kidney disease (CKD) patients has been increasing over the past two decades, both globally and in Egypt. In our current study we tried to identify the pattern of end-stage renal patients [chronic kidney disease stage 5 (CKD5)], who presented at a tertiary referral center (Cairo University Hospital, Kasr-Alainy School of Medicine), to identify the epidemiological characteristics, clinical presentation, hospital course, and outcome.

Patients and methods

This is a prospective analysis of all medical admissions through the emergency department (Department 6) of Kasr-Alainy School of Medicine, Cairo University, in 1 year from July 2010 to July 2011. We included patients with proven CKD 5 who needed to be started on renal replacement therapy.

Results

A total of 571 patients were identified, of whom 82 patients (36 males and 46 females) proved to have CKD5 and needed to be started on renal replacement therapy. The mean age of the included patients was 51.63 ± 14.7 years. Oliguria and vomiting were the most frequent symptoms, as seen in 52 cases (63.4%), followed by symptoms of volume overload in 24 patients (29.3%) and disturbed level of consciousness and fever in six patients (7.3%). Diabetic nephropathy was the most common cause of renal failure in our studied cohort (51.2%), followed by hypertension (22%); the cause was unknown in 25% of patients. Four patients (4.9%) died during their hospital stay.

Conclusion

In conclusion, our study showed that there is delayed referral for nephrology care and delayed initiation of dialysis when patients presented through the emergency department. Of particular interest was the fact that diabetic patients were most often subjected to this practice.

References

  1. Soliman AR, Fathy A, Roshd D. The growing burden of end-stage renal disease in Egypt. Ren Fail 2012; 34:425–428.

    Article  Google Scholar 

  2. Barsoum R. Burden of chronic kidney disease. Kidney Int Suppl 2013; 3:164–166.

    Article  Google Scholar 

  3. Arıkan H. Serhan Tuğlular the growing global burden of end stage renal disease. Marmara Med J 2005; 18:143–150.

    Google Scholar 

  4. Ahmed AM, Allam MF, Habil ES, Metwally AM, Ibrahiem NA, Radwan M, et al. Development of practice guidelines for hemodialysis in Egypt. Indian J Nephrol 2010; 20:193–202.

    Article  CAS  Google Scholar 

  5. Tzamaloukas AH, Raj DS. Referral of patients with chronic kidney disease to the nephrologist: why and when. Perit Dial Int 2008; 28: 343–346.

    Article  Google Scholar 

  6. Reutens AT, Prentice L, Atkins R. The epidemiology of diabetic kidney disease. In: Ekoe J, ed. The epidemiology of diabetes mellitus. 2nd ed. Chichester: John Wiley & Sons Ltd. 2008;499–518.

    Chapter  Google Scholar 

  7. Eadington DW. Delayed referral for dialysis: higher morbidity and higher costs. Semin Dial 1995; 8:258–260.

    Article  Google Scholar 

  8. Jungers P, Zingraff J, Albouze G, Chauveau P, Page B, Hannedouche T, Man NK. Late referral to maintenance dialysis: detrimental consequences. Nephrol Dial Transplant 1993; 8:1089–1093.

    CAS  PubMed  Google Scholar 

  9. Friedlander MA, Hricik DE. Optimizing end-stage renal disease therapy for the patient with diabetes mellitus. Semin Nephrol 1997; 17:331–345.

    CAS  PubMed  Google Scholar 

  10. De Boer IH. Chronic kidney disease – a challenge for all ages. JAMA 2012; 308:2401–2402.

    Article  Google Scholar 

  11. Chan MR, Dall AT, Fletcher KE, Lu N, Trivedi H. Outcomes in patients with chronic kidney disease referred late to nephrologists: a meta-analysis. Am J Med 2007; 120:1063–1070.

    Article  Google Scholar 

  12. Eadington DW. Delayed referral for dialysis. Nephrol Dial Transplant 1996; 11:2124–2126.

    Article  CAS  Google Scholar 

  13. Ismail N, Neyra R, Hakim R. The medical and economical advantages of early referral of chronic renal failure patients to renal specialists. Nephrol Dial Transplant 1998; 13:246–250.

    Article  CAS  Google Scholar 

  14. Batieha A, Abdalla S, Maghairah Z, et al. Epidemiology and cost of hemodialysis in Jordon. The health review of oriental Mediterranean countries 2007; 13:3.

    Google Scholar 

  15. Hansberry MR, Whittier WL, Krause MW. The elderly patient with chronic kidney disease. Adv Chronic Kidney Dis 2005; 12:71–77.

    Article  Google Scholar 

  16. Lehmann PR, Ambühl M, Corleto D, Klaghofer R, Ambühl PM. Epidemiologic trends in chronic renal replacement therapy over forty years: a Swiss dialysis experience, BMC Nephrol 2012; 13:52.

    Article  Google Scholar 

  17. Ethier J, Mendelssohn DC, Elder SJ, Hasegawa T, Akizawa T, Akiba T, et al. Vascular access use and outcomes: an international perspective from the Dialysis Outcomes and Practice Patterns Study. Nephrol Dial Transplant 2008; 23:3219–3226.

    Article  Google Scholar 

  18. United States renal data system: USRDS 2004 annual data report: atlas of end-stage renal disease in the United States. Bethesda: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2004

  19. Soucie JM, McClellan WM. Early death in dialysis patients: risk factors and impact on incidence and mortality rates. J Am Soc Nephrol 1996; 7:2169–2175.

    CAS  PubMed  Google Scholar 

  20. Kessler M, Frimat L, Panescu V, Briançon S. Impact of nephrology referral on early and midterm outcomes in ESRD: EPidemiologie de l’Insuffisance REnale chronique terminale en Lorraine (EPIREL): results of a 2-year, prospective, community-based study. Am J Kidney Dis 2003; 42:474–485.

    Article  Google Scholar 

  21. Lin CL, Chuang FR, Wu CF, Yang CT. Early referral as an independent predictor of clinical outcome in end-stage renal disease on hemodialysis and continuous ambulatory peritoneal dialysis. Ren Fail 2004; 26:531–537.

    Article  Google Scholar 

  22. Innes A, Rowe PA, Burden RP, Morgan AG. Early deaths on renal replacement therapy: the need for early nephrological referral. Nephrol Dial Transplant 1992; 7:467–471.

    Article  CAS  Google Scholar 

  23. Khan IH, Catto GR, Edward N, MacLeod AM. Death during the first 90 days of dialysis: a case control study. Am J Kidney Dis 1995; 25:276–280.

    Article  CAS  Google Scholar 

  24. Barsoum RS, Francis MR. Spectrum of glomerulonephritis in Egypt. Saudi J Kidney Dis Transpl 2000; 11:421–429.

    CAS  PubMed  Google Scholar 

  25. Barsoum RS. Chronic kidney disease in the developing world. N Engl J Med 2009; 354:997–999.

    Article  Google Scholar 

  26. Athuraliya TNC, Abeysekera DTDJ, Amerasinghe PH, Kumarasiri PVR, Dissanayake V. Prevalence of chronic kidney disease in two tertiary care hospitals: high proportion of cases with uncertain etiology. Ceylon Med J 2009; 54:23–25.

    Article  CAS  Google Scholar 

  27. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet 2013; 382(9888): 260–272.

    Article  Google Scholar 

  28. El-Zanaty F, Way A. Egypt demographic and health survey 2008. Cairo, Egypt: Ministry of Health, El-Zanaty and Associates, and Macro International; 2009.

    Google Scholar 

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Correspondence to Hatem Darwish MD.

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Ibrahim, S., Darwish, H. & Fayed, A. Late initiation of dialysis in diabetic Egyptian patients. Egypt J Intern Med 27, 58–62 (2015). https://doi.org/10.4103/1110-7782.159450

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