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The Egyptian Journal of Internal Medicine
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Looking for the early marker of renal injury

The Egyptian Journal of Internal Medicine volume 27, pages 45–47 (2015)Cite this article

Abstract

Acute Kidney Injury is a complex and increasingly common syndrome. Practically all available markers reflect functional impairment rather than a true direct mark of cellular injury. An ideal AKI biomarker should be accurate, reliable, easy to measure with a standard assay, noninvasive, reproducible, and sensitive and specific with defined cutoff values. Studies have identified a relatively small number of genes that are specifically altered in acute renal tubular injury. Kim-1 is one of the best-characterized urinary biomarkers to date in both experimental animals and humans with renal disease. Also NGAL is at the top of many researchers’ lists. Other biomarkers include IL-18, N-acetyl-β-d-glucosaminidase, and urinary liver-type fatty acid binding protein.

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Authors and Affiliations

  1. Department of Internal Medicine and Nephrology, Cairo University, Giza, Egypt

    Ahmed S. A. Zaky MD

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  1. Ahmed S. A. Zaky MD
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Correspondence to Ahmed S. A. Zaky MD.

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Zaky, A.S.A. Looking for the early marker of renal injury. Egypt J Intern Med 27, 45–47 (2015). https://doi.org/10.4103/1110-7782.159446

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  • DOI: https://doi.org/10.4103/1110-7782.159446

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