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A case report of recurrent hypokalaemic periodic paralysis in a young male patient

Abstract

A 21-year-old normotensive male patient presented with acute-onset flaccid paralysis with the history of a similar episode a few months back. Clinical and laboratory evaluation revealed lower motor neuron type of flaccid quadriparesis with hypokalaemia, normal anion gap metabolic acidosis, bicarbonaturia and transtubular potassium concentration gradient more than 7. Subsequently, urine acidification test (by ammonium chloride challenge test) was performed and diagnosis of renal tubular acidosis was established. The patient ultrasound did not show nephrocalcinosis, and history of recurrent diarrhoea preceding the attack revealed that the patient also had coeliac disease. The patient responded to conservative management (Sohl’s solution) and gluten-free diet.

References

  1. Laing CM, Toye AM, Capasso G, Unwin RJ. Renal tubular acidosis: developments in our understanding of the molecular basis. Int J Biochem Cell Biol 2005; 37:1151–1161.

    Article  CAS  Google Scholar 

  2. Buckalew VM Jr. Nephrolithiasis in renal tubular acidosis. J Urol 1989; 141:731–737.

    Article  Google Scholar 

  3. Walsh SB, Shirley DG, Wrong OM, Unwin RJ. Urinary acidification assessed by simultaneous furosemide and fludrocortisones treatment: an alternative to ammonium chloride. Kidney Int 2007; 71: 1310–1316.

    Article  CAS  Google Scholar 

  4. Wrong O, Davies HEF. The excretion of acid in renal disease. QJM 1959; 28:259–313.

    CAS  PubMed  Google Scholar 

  5. Wrong OM, Feest TG, MacIver AG. Immune-related potassium-losing interstitial nephritis: a comparison with distal renal tubular acidosis. Q J Med 1993; 86:513–534.

    Article  CAS  Google Scholar 

  6. Skinner R, Pearson AD, English MW, Price L, Wyllie RA, Coulthard MG, Craft AW. Risk factors for ifosfamide nephrotoxicity in children. Lancet 1996; 348:578–580.

    Article  CAS  Google Scholar 

  7. Batlle DC, Sabatini S, Kurtzman NA. On the mechanism of toluene-induced renal tubular acidosis. Nephron 1988; 49:210–218.

    Article  CAS  Google Scholar 

  8. Boton R, Gaviria M, Batlle DC. Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy. Am J Kidney Dis 1987; 10:329–345.

    Article  CAS  Google Scholar 

  9. McCurdy DK, Frederic M, Elkinton JR. Renal tubular acidosis due to amphotericin B. N Engl J Med 1968; 278:124–130.

    Article  CAS  Google Scholar 

  10. Koul PA, Saleem SM. Chronic active hepatitis with renal tubular acidosis presenting as hypokalemic periodic paralysis with respiratory failure. Acta Paediatr 1992; 81:568–569.

    Article  CAS  Google Scholar 

  11. Viscomi CM, Ptacek LJ, Dudley D. Anesthetic management of familial hypokalemic periodic paralysis during parturition. Anesth Analg 1999; 88: 1081–1082.

    Article  CAS  Google Scholar 

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Correspondence to Vikas T. Talreja.

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Gupta, P., Talreja, V.T., Dhananjaya, M.S. et al. A case report of recurrent hypokalaemic periodic paralysis in a young male patient. Egypt J Intern Med 27, 72–74 (2015). https://doi.org/10.4103/1110-7782.158001

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  • DOI: https://doi.org/10.4103/1110-7782.158001

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