Skip to main content
The Egyptian Journal of Internal Medicine
Download PDF

Nonreversal of adrenal hypofunction after treatment of adrenal tuberculosis

The Egyptian Journal of Internal Medicine volume 27, pages 42–44 (2015)Cite this article

Abstract

Tuberculosis of the adrenal glands is a common cause for Addison’s disease in developing countries. Whether treatment of tuberculosis normalizes adrenocortical function in these patients is controversial. We are reporting two cases of Addison’s disease because of adrenal tuberculosis, in whom treatment with antitubercular drugs did not restore normal adrenal functions. We conclude that treatment of tubercular Addison’s disease does not lead to normalization of adrenocortical function.

References

  1. Agarwal G, Bhatia E, Pandey R, Jain SK. Clinical profile and prognosis of Addison’s disease in India. Natl Med J India 2001; 14:23–25.

    CAS  PubMed  Google Scholar 

  2. Kelestimur F, Unlui Y, Ozesmi M, Tolu I. A hormonal and radiological evaluation of adrenal gland in patients with acute and chronic pulmonary tuberculosis. J Endocrinol 1993; 137(Suppl):p. 26.

    Google Scholar 

  3. Zargar AH, Sofi FA, Akhtar MA, Salahuddin M, Masoodi SR, Laway BA. Adrenocortical reserve in patients with active tuberculosis. J Pak Med Assoc 2001; 51:427–433.

    CAS  PubMed  Google Scholar 

  4. Penrice J, Nussey SS. Recovery of adrenocortical function following treatment of tuberculous Addison’s disease. Postgrad Med J 1992; 68:204–205.

    Article  CAS  Google Scholar 

  5. Keleştimur F. Recovery of adrenocortical function following treatment of tuberculous Addison’s disease. Postgrad Med J 1993; 69:832.

    Article  Google Scholar 

  6. Bhatia E, Jain SK, Gupta RK, Pandey R. Tuberculous Addison’s disease: lack of normalization of adrenocortical function after anti-tuberculous chemotherapy. Clin Endocrinol (Oxf) 1998; 48:355–359.

    Article  CAS  Google Scholar 

  7. Wilkins EG, Hnizdo E, Cope A. Addisonian crisis induced by treatment with rifampicin. Tubercle 1989; 70:69–73.

    Article  CAS  Google Scholar 

  8. Guttman PH. Addison’s disease; statistical analysis of 566 cases and a study of the pathology. Arch pathol 1930; 10:742–785.

    Google Scholar 

  9. Dunlop D. Eighty-six cases of Addison’s disease. Br Med J 1963; 2:887–891.

    Article  CAS  Google Scholar 

  10. Nerup J. Addison’s disease – clinical studies. A report of 108 cases. Acta Endocrinol (Copenh) 1974; 76:127–141.

    CAS  Google Scholar 

  11. Ellis ME, Tayoub F. Adrenal function in tuberculosis. Br J Dis Chest 1986; 80:7–12.

    Article  CAS  Google Scholar 

  12. Barnes DJ, Naraqi S, Temu P, Turtle JR. Adrenal function in patients with active tuberculosis. Thorax 1989; 44:422–424.

    Article  CAS  Google Scholar 

  13. Francois Venter WD, Panz VR, Feldman C, Joffe BI. Adrenocortical function in hospitalised patients with active pulmonary tuberculosis receiving a rifampicin-based regimen – a pilot study. S Afr Med J 2006; 96:62–66.

    CAS  PubMed  Google Scholar 

  14. Laway BA, Khan I, Shah BA, Choh NA, Bhat MA, Shah ZA. Pattern of adrenal morphology and function in pulmonary tuberculosis: response to treatment with antitubercular therapy. Clin Endocrinol (Oxf) 2013; 79:321–325.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India

    Bashir Ahmad Laway (Professor and HOD) & Mohd Ashraf Ganie

  2. Department of Radiodiagnosis, Sher-I-Kashmir Institute of Medical Sciences, India

    Feroze Shaheen

  3. Department of Internal Medicine and Endocrinology, Government Medical College, Srinagar, Jammu and Kashmir, India

    Shahnaz Ahmad Mir & Parvaiz Ahmad Shah

Authors
  1. Bashir Ahmad Laway
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shahnaz Ahmad Mir
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohd Ashraf Ganie
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Feroze Shaheen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Parvaiz Ahmad Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bashir Ahmad Laway.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Laway, B.A., Mir, S.A., Ganie, M.A. et al. Nonreversal of adrenal hypofunction after treatment of adrenal tuberculosis. Egypt J Intern Med 27, 42–44 (2015). https://doi.org/10.4103/1110-7782.155860

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/1110-7782.155860

Keywords