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Pulmonary Langerhans cell histiocytosis causing spontaneous bilateral pneumothorax in a child


Bilateral pneumothorax is very rare in childhood. Moreover, if it is due to pulmonary involvement of Langerhans cell histiocytosis, it is even rarer in childhood. In our case, a nonsmoker 12-year-old boy presented with bilateral pneumothorax, whose high-resolution computed tomography scan was highly suggestive of pulmonary Langerhans cell histiocytosis. Excision biopsy of a clinically palpable cervical lymph node and histopathological examination and immunohistochemistry positivity for CD1a indicated a diagnosis of Langerhans cell histiocytosis. Clinicians should consider pulmonary Langerhans cell histiocytosis in differential diagnoses in dealing such a case.


  1. Savasta S, Leoni MC, Strocchio L, Pizzo D, Spartà MV, Lima M, et al. A rare cause of recurrent spontaneous pneumothorax. Clin Pediatr (Phila) 2011; 50:456–458.

    Article  Google Scholar 

  2. Hofmann LJ, Hetz SP. Pediatric bilateral spontaneous pneumothoraces in monozygotic twins. Pediatr Surg Int 2012; 28:745–749.

    Article  Google Scholar 

  3. Didilis VN, Bitzikas GI, Mikroulis DA, Bougioukas GI. Pulmonary invasion in multisystem Langerhans cell histiocytosis. Ann Thorac Surg 2003; 75: 1656.

    Article  Google Scholar 

  4. Vassallo R, Ryu JH, Colby TV, Hartman T, Limper AH. Pulmonary Langerhans’ cell histiocytosis. N Engl J Med 2000; 342:1969–1978.

    Article  CAS  Google Scholar 

  5. Tazi A, Soler P, Hance AJ. Adult pulmonary Langerhans’ cell histiocytosis. Thorax 2000; 55:405–416.

    Article  CAS  Google Scholar 

  6. Salotti JA, Nanduri V, Pearce MS, Parker L, Lynn R, Windebank KP. Incidence and clinical features of Langerhans cell histiocytosis in the UK and Ireland. Arch Dis Child 2009; 94:376–380.

    Article  CAS  Google Scholar 

  7. Ronceray L, Pötschger U, Janka G, Gadner H, Minkov M, German Society for Pediatric Hematology and Oncology, Langerhans Cell Histiocytosis Study Group. Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome. J Pediatr 2012; 161:129–133.

    Article  Google Scholar 

  8. Chikwava K, Jaffe R. Langerin (CD207) staining in normal pediatric tissues, reactive lymph nodes, and childhood histiocytic disorders. Pediatr Dev Pathol 2004; 7:607–614.

    Article  CAS  Google Scholar 

  9. Wells AU. The clinical utility of bronchoalveolar lavage in diffuse parenchymal lung disease. Eur Respir Rev 2010; 19:237–241.

    Article  CAS  Google Scholar 

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Correspondence to Anupam Patra MD.

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Patra, A., Bhattacharyay, S.K., Maji, A. et al. Pulmonary Langerhans cell histiocytosis causing spontaneous bilateral pneumothorax in a child. Egypt J Intern Med 27, 38–39 (2015).

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  • bilateral pneumothorax
  • childhood
  • pulmonary Langerhans cell histiocytosis