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The Egyptian Journal of Internal Medicine
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Fetuin-A and type II diabetes mellitus

The Egyptian Journal of Internal Medicine volume 26, pages 157–161 (2014)Cite this article

Abstract

Background

The pathophysiology of type II DM is complex; in addition to impaired insulin secretion from Beta-cells, reduced insulin sensitivity was found to play a predominant role in the pathogenesis of the disease. Fetuin-A is a hepatic secretory protein that binds the insulin receptor and inhibits insulin action both in vivo and in vitro.

Objective

Our aim was to investigate whether serum fetuin-A levels predict the incidence of insulin resistance in type II DM.

Patient and methods

The present study included 40 patients who had type II diabetes mellitus served as patients group and 40 apparently normal individuals served as control group. All patient and control groups were subjected to the following: full medical history and thorough physical examination, fasting & post prandial blood glucose, urea, creatinine, lipid profile, CRP, insulin and fetuin-A.

Results

There was highly significant increase in serum insulin, serum fetuin A and HOMA-IR in diabetic group compared with control group. There was significant positive correlation between serum fetuin A and serum insulin, FBG, HbA1c and serum CRP. Also a significant positive correlation between HOMA-IR and serum fetuin A, serum insulin and HbA1c were found.

Conclusion

We concluded that fetuin-A may play a role in the pathogenesis of type II DM, and high serum fetuin-A has a strong association with IR and glycemic control in type II diabetic patients. Future studies are recommended to establish the possibility of using fetuin-A as a predictor of insulin resistance in type II diabetic patients.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Egypt

    Lamyaa Ismail Ahmed MD, Sabila Gomaa Mousa, Zeinab Ahmed Yousry & Mayada Rabea Abd-El Khalaa

  2. Department of Clinical and Chemical Pathology, National Research Center, Cairo, Egypt

    Nagwa Abd El-Ghaffar Mohamed

Authors
  1. Lamyaa Ismail Ahmed MD
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  2. Sabila Gomaa Mousa
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  3. Nagwa Abd El-Ghaffar Mohamed
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  4. Zeinab Ahmed Yousry
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  5. Mayada Rabea Abd-El Khalaa
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Correspondence to Lamyaa Ismail Ahmed MD.

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Ahmed, L.I., Mousa, S.G., Mohamed, N.A.EG. et al. Fetuin-A and type II diabetes mellitus. Egypt J Intern Med 26, 157–161 (2014). https://doi.org/10.4103/1110-7782.148140

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