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The Egyptian Journal of Internal Medicine
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The association between the melatonin receptor 1B gene polymorphism rs10830963 and glucose levels in type 2 diabetes

The Egyptian Journal of Internal Medicine volume 26, pages 145–150 (2014)Cite this article

Abstract

Introduction

Melatonin is a pineal hormone under the control of the biological clock, which is located in the hypothalamus and regulated by light exposure. Melatonin receptors have been found throughout the body in many tissues including pancreatic islet cells, reflecting the widespread effects of melatonin on physiological functions such as energy metabolism and the regulation of body weight. Several lines of evidence suggest that melatonin may play a role in glucose metabolism.

Aim of the work

To investigate the association between diabetes mellitus (T2D) and the variants rs10830963 in the melatonin receptor 1B gene (MTNR1B) locus in a sample of the Egyptian population.

Patients and method

This was a case–control study conducted in the internal medicine department at El-Kasr El-Aini Hospital, Cairo University.

It included 30 diabetic individuals (type 2) compared with 20 healthy individuals. All individuals included in the study were subjected to a detailed history taking, complete physical examination, body composition evaluation, and laboratory testing including blood picture, blood urea nitrogen, creatinine, lipid profile, and genotyping of melatonin receptor B1. Diabetic individuals were subtyped into three groups: (a) Diabetic patients without complications. (b) Diabetic patients with microvascular complications. (c) Diabetic patients with macrovascular complications.

Results

Statistical analysis revealed a significant positive correlation between the MTNR1B polymorphism rs10830963 and glucose levels in type 2 diabetes.

Conclusion

The study confirmed that individuals having the MTNR1B gene polymorphism are at a greater risk of developing type 2 diabetes and having higher blood glucose levels and are more prone to be dyslipidemic than others who have no polymorphism.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, 11688, Egypt

    Tarek S. Heshmat, Heba Sh. Kareem & Noha Kh M. Khalil MD

  2. Department of Biochemistry, Faculty of medicine, Cairo University, Cairo, Egypt

    Olfat G. Shaker

Authors
  1. Tarek S. Heshmat
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  2. Heba Sh. Kareem
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  3. Noha Kh M. Khalil MD
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  4. Olfat G. Shaker
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Correspondence to Noha Kh M. Khalil MD.

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Heshmat, T.S., Kareem, H.S., Khalil, N.K.M. et al. The association between the melatonin receptor 1B gene polymorphism rs10830963 and glucose levels in type 2 diabetes. Egypt J Intern Med 26, 145–150 (2014). https://doi.org/10.4103/1110-7782.148120

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  • DOI: https://doi.org/10.4103/1110-7782.148120

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