Table 4 Relation between body weight subcategories and daily Levothyroxine dose and weight-based L-T4 dose in each group

Group 1

(n = 87)

Daily L-T4 dose

(n = 22)

(n = 48)

(n = 17)

Mean ± SD

70.86 ± 17.53

81.98 ± 16.73

103.6 ± 36.86

0.002^*

Median

(min.–max.)

67.50

(50.0 114.0)

85.0

(50.0–128.0)

100.0

(50.0–165.0)

L-T4 dose (µg/kg/day)

(n = 22)

(n = 48)

(n = 17)

Mean ± SD

1.14 ± 0.26

0.97 ± 0.19

0.93 ± 0.32

0.024^*

Median

(min.–max.)

1.09

(0.77–1.71)

0.98

(0.52–1.36)

0.86

(0.48–1.58)

Group 2

(n = 95)

Daily L-T4 dose

(n = 17)

(n = 59)

(n = 19)

Mean ± SD

79.65 ± 18.40

96.80 ± 20.82

116.5 ± 28.42

< 0.001^*

Median

(min.–max.)

75.0

(50.00–107.0)

100.0

(50.00–171.0)

112.5

(85.00–200.0)

L-T4 dose (µg/kg/day)

(n = 17)

(n = 59)

(n = 19)

Mean ± SD

1.29 ± 0.27

1.17 ± 0.26

1.03 ± 0.21

0.004^*

Median

(min.–max.)

1.32

(0.82–1.76)

1.13

(0.68–2.19)

0.98

(0.74–1.58)

Group 3

(n = 75)

Daily L-T4 dose

(n = 18)

(n = 45)

(n = 12)

Mean ± SD

87.81 ± 15.78

118.8 ± 24.68

148.6 ± 38.16

< 0.001^*

Median

(Min.–Max.)

89.0

(57.0–114.0)

114.0

(43.0–185.0)

139.0

(114.0–250.0)

L-T4 dose (µg/kg/day)

(n = 18)

(n = 45)

(n = 12)

Mean ± SD

1.44 ± 0.33

1.42 ± 0.29

1.30 ± 0.27

0.091

Median

(Min.–max.)

1.40

(0.85–2.36)

1.37

(0.61–2.45)

1.25

(1.08–2.07)

Group 4

(n = 91)

Daily L-T4 dose

(n = 15)

(n = 59)

(n = 17)

Mean ± SD

87.67 ± 17.25

102.2 ± 27.09

138.2 ± 37.56

< 0.001^*

Median

(Min.–max.)

85.0

(64.0–121.0)

100.0

(53.0–200.0)

143.0

(71.0–215.0)

L-T4 dose (µg/kg/day)

(n = 15)

(n = 59)

(n = 17)

Mean ± SD

1.43 ± 0.35

1.19 ± 0.29

1.20 ± 0.31

0.072

Median

(Min.–max.)

1.32

(1.05–2.14)

1.14

(0.60–2.27)

1.17

(0.71–1.83)