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Table 1 Comparison between the different studied groups according to demographic data

From: Real-world derived weight-based levothyroxine doses to achieve optimal thyrotropin target in different degrees of autoimmune hypothyroidism

Demographic data

Group 1

(n = 87)

Group 2

(n = 95)

Group 3

(n = 75)

Group 4

(n = 91)

Test of Sig

p

Sex

 Female

86 (98.9%)

91 (95.8%)

68 (90.7%)

89 (97.8%)

χ2 = 

6.871

MCp = 

0.064

 Male

1 (1.1%)

4 (4.2%)

7 (9.3%)

2 (2.2%)

Age (years)

 < 60

79 (90.8%)

79 (83.2%)

56 (74.7%)

65 (71.4%)

χ2 = 

12.526*

0.006*

 ≥ 60

8 (9.2%)

16 (16.8%)

19 (25.3%)

26 (28.6%)

 Mean ± SD

41.1 ± 11.1

43.5 ± 14.6

45.6 ± 15.4

49.5 ± 13.5

F = 

6.073*

< 0.001*

 Median (min.–max.)

38 (17–71)

41 (14–76)

43 (18–82)

50 (20–77)

   Sig. bet. grps

p1 = 0.638, p2 = 0.154, p3 < 0.001*, p4 = 0.744, p5 = 0.016*, p6 = 0.269

  

Body weight (kg)

 < 70

22 (25.3%)

17 (17.9%)

18 (24%)

15 (16.5%)

χ2=

3.566

0.735

 70–100

48 (55.2%)

59 (62.1%)

45 (60%)

59 (64.8%)

 > 100

17 (19.5%)

19 (20%)

12 (16%)

17 (18.7%)

 Mean ± SD

84.5 ± 19

85 ± 18.1

83.7 ± 18.9

87.3 ± 17.9

F = 

0.620

0.603

 Median (min.–max.)

82 (51.7–161.7)

81.7 (53.7–151)

82 (36–146.5)

86.7 (52.7–134)

  1. Group 1 mild subclinical hypothyroidism, Group 2 severe subclinical hypothyroidism, Group 3 overt hypothyroidism, Group 4 hypothyroidism unknown
  2. SD standard deviation, F F for one-way ANOVA test, χ2 chi-square test, MC Monte Carlo, H H for Kruskal–Wallis test, pairwise comparison between each 2 groups was done using post hoc test (Dunn’s for multiple comparisons test)
  3. p p value for comparing between the studied groups
  4. p1 p value for comparing between Group 1 and Group 2
  5. p2: p value for comparing between Group 1 and Group 3
  6. p3: p value for comparing between Group 1 and Group 4
  7. p4: p value for comparing between Group 2 and Group 3
  8. p5: p value for comparing between Group 2 and Group 4
  9. p6: p value for comparing between Group 3 and Group 4
  10. *Statistically significant at p ≤ 0.05