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The Egyptian Journal of Internal Medicine

Table 4 Diagnostic criteria of serpin (serum and urinary) as biomarkers for transition of AKI to CKD prediction

From: Epidemiology, risk factors, outcomes, and role of Serpin A3 as a biomarker for transition of acute kidney injury to chronic kidney disease in critically ill patients

Diagnostic criteria

S. serpin

U. serpin

• AUCa

0.819

0.882

• 95% CI

0.656–0.983

0.737–1.000

• SEb

0.083

0.074

• p-valuec

 = 0.017

 = 0.004

• Cutoff

117

113

• Accuracy

82%

84%

• Sensitivity%

100%

100%

• Specificity%

64%

68%

• PPV%

73.5%

74.5%

• NPV%

100%

100%

  1. aAUC area under the curve
  2. bSE standard error. CI confidence interval
  3. cNull hypothesis: true area = 0.5. ––Sensitivity (true positives/all diseased), specificity (true negatives/all non-diseased), PPV (true positives/all test positives), NPV (true negatives/all test negatives)
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