Table 2 Association analysis of serum IL-36α and IL-38 levels with risk of type 2 diabetes mellitus without and with diabetic neuropathy
Cytokine group | T2D (n = 85) | DNP (n = 21) | HC (n = 109) | T2D vs. HC | DNP vs. HC | ||
|---|---|---|---|---|---|---|---|
OR (95% CI) | p-value | OR (95% CI) | p-value | ||||
IL-36α | |||||||
LP; n (%) | 10 (11.8) | 7 (33.3) | 91 (83.5) | Reference; 1.0 | Reference; 1.0 | ||
HP; n (%) | 75 (88.2) | 14 (66.7) | 18 (16.5) | 37.92 (16.59–86.67) | < 0.001 | 10.11 (3.65–28.00) | < 0.001 |
IL-38 | |||||||
LP; n (%) | 13 (15.3) | 3 (14.3) | 92 (84.4) | Reference; 1.0 | Reference; 1.0 | ||
HP; n (%) | 72 (84.7) | 18 (85.7) | 17 (15.6) | 29.97 (13.73–65.45) | < 0.001 | 32.47 (8.86–119.05) | < 0.001 |