Fig. 4

Prediction of the protein-protein interaction network IL-36α (A IL36A) and IL-38 (B IL1F10) with relevant proteins (interaction score > 0.75) as revealed by STRING analysis (https://string-db.org). Colored nodes indicate IL-36α, IL-38, and first shell of interactions. Edges indicate IL-36α- and IL-38-protein association. Connections were identified as colored lines. IL1A, IL-1α; IL1RL2, IL-1 receptor-like 2; IL1RAP, IL-1 receptor accessory protein; IL1RAPL1, IL-1 receptor accessory protein-like-1; IL36RN, IL-36 receptor antagonist protein; IL1R1, IL-1 receptor type 1; KPNA7, karyopherin subunit alpha 7