Role of serum micro-RNA 486-5p in Egyptian cirrhotic hepatitis C patients with hepatocellular carcinoma

The Egyptian Journal of Internal Medicine

Table 4 Validity (AUC, sensitivity, specificity) for miRNA 486-5p and AFP to diagnosis HCC (n = 25) from cirrhosis (n = 25)

	AUC	p	95% CI	Cutoff	Sensitivity	Specificity	PPV	NPV
Micro-RNA 486-5p	0.667	0.043^*	0.512–0.822	> 1.22^a	60.0	76.0	71.4	65.5
Alpha-fetoprotein	0.712	0.010^*	0.565–0.859	> 100	36.0	76.0	60.0	54.3

CI confidence interval, NPV negative predictive value, PPV positive predictive value
^*Statistically significant at p ≤ 0.05
^aCutoff was chosen according to the Youden index