Serum fatty acid-binding protein 4 as a biomarker for early detection of diabetic nephropathy in type 2 diabetes

Shaker, Amr M.; Mohamed, Maggie E.; Ramzy, Tarek; Ali, Mayssa I.

doi:10.1186/s43162-023-00200-9

The Egyptian Journal of Internal Medicine

Table 5 Comparison between studied groups regarding glycemic parameters

From: Serum fatty acid-binding protein 4 as a biomarker for early detection of diabetic nephropathy in type 2 diabetes

	Normal control		Normoalbuminuria (< 30 mg/gm)		Microalbuminuria (30–300 mg/gm)		Macroalbuminuria (> 300 mg/gm)		P value		FABP4
FBS (mg/dl)	81.50 ± 9.72		165.14 ± 9.9		185.50 ± 8.3		230.8 ± 8.14		< 0.001
HBA1c	5.02 ± 0.31		7.29 ± 0.44		8.41 ± 0.46		9.98 ± 0.87		< 0.001		< 0.001
				Normal control		Normoalbuminuria (< 30 mg/gm)		Microalbuminuria (30–300 mg/gm)		Macroalbuminuria
Age		Normal control				0.220		0.071		0.007
		Normoalbuminuria		0.220				1.000		1.000
		Microalbuminuria		0.071		1.000				1.000
		Macroalbuminuria		0.007		1.000		1.000
HB		Normal control				< 0.001		< 0.001		< 0.001
		Normoalbuminuria		< 0.001				0.038		1.000
		Microalbuminuria		< 0.001		0.038				0.070
		Macroalbuminuria		< 0.001		1.000		0.070
PLT		Normal control				< 0.001		0.633		< 0.001
		Normoalbuminuria		< 0.001				0.006		1.000
		Microalbuminuria		0.633		0.006				0.047
		Macroalbuminuria		< 0.001		1.000		0.047
Creat		Normal control				< 0.001		< 0.001		< 0.001
		Normoalbuminuria		< 0.001				< 0.001		< 0.001
		Microalbuminuria		< 0.001		< 0.001				< 0.001
		Macroalbuminuria		< 0.001		< 0.001		< 0.001
GFR %		Normal control				< 0.001		< 0.001		< 0.001
		Normoalbuminuria		< 0.001				0.020		< 0.001
		Microalbuminuria		< 0.001		0.020				0.522
		Macroalbuminuria		< 0.001		< 0.001		0.522
S. albumin		Normal control				< 0.001		< 0.001		< 0.001
		Normoalbuminuria		< 0.001				0.015		< 0.001
		Microalbuminuria		< 0.001		0.015				< 0.001
		Macroalbuminuria		< 0.001		< 0.001		< 0.001
Ca		Normal control				< 0.001		< 0.001		< 0.001
		Normoalbuminuria		< 0.001				1.000		0.715
		Microalbuminuria		< 0.001		1.000				1.000
		Macroalbuminuria		< 0.001		0.715		1.000
Phosphorus		Normal control				< 0.001		< 0.001		0.004
		Normoalbuminuria		< 0.001				1.000		1.000
		Microalbuminuria		< 0.001		1.000				0.779
		Macroalbuminuria		0.004		1.000		0.779
FABP		Normal control				0.016		< 0.001		< 0.001
		Normoalbuminuria		0.016				< 0.001		< 0.001
		Microalbuminuria		< 0.001		< 0.001				< 0.001
		Macroalbuminuria		< 0.001		< 0.001		< 0.001

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