Table 3 The curve of receiver operating characteristic (ROC) of the studied indices for optimum cutoff points in differentiating iron deficiency anemia from the study other hemoglobinopathy groups
Indices | Cutoff | AUC | 95% CI | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Youden index (%) | p-value |
|---|---|---|---|---|---|---|---|---|---|
RDWI | > 241.58 | 0.547 | (0.478, 0.615) | 81.63 | 47.9 | 31.5 | 89.9 | 29.54 | 0.229 |
ML_I | > 14.64 | 0.612 | (0.543, 0.677) | 89.80 | 46.11 | 32.8 | 93.9 | 35.9 | 0.003* |
GK | ≤ 103.56 | 0.602 | (0.534, 0.668) | 97.96 | 31.74 | 29.6 | 98.1 | 29.7 | 0.007* |
EF | ≤ 18.5 | 0.639 | (0.572, 0.703) | 91.84 | 43.11 | 32.1 | 94.7 | 34.95 | 0.002* |
SL | > 901.58 | 0.574 | (0.505, 0.640) | 95.92 | 31.74 | 29.2 | 96.4 | 27.65 | 0.054 |
SI | ≤ 6.37 | 0.530 | (0.461, 0.598) | 95.92 | 29.94 | 28.7 | 96.2 | 25.86 | 0.449 |
RI | ≤ 5.18 | 0.568 | (0.499, 0.635) | 95.92 | 28.74 | 28.3 | 96 | 24.66 | 0.081 |
EI | > 25 | 0.616 | (0.547, 0.681) | 81.63 | 56.29 | 35.4 | 91.3 | 37.92 | 0.002* |
Sir_I | ≤ 43.4 | 0.517 | (0.449, 0.586) | 100 | 26.95 | 28.7 | 100 | 26.95 | 0.655 |
HH | ≤ 29.81 | 0.622 | (0.553, 0.686) | 93.88 | 37.13 | 30.5 | 95.4 | 31 | 0.001* |