Table 2 The curve of receiver operating characteristic (ROC) of the studied indices for optimum cutoff points in differentiating the study hemoglobinopathy groups from each other
Indices | Cutoff | AUC | 95% CI | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Youden index (%) | p-value |
|---|---|---|---|---|---|---|---|---|---|
Quantitative hemoglobinopathy (β-thalassemia) | |||||||||
 RDWI | ≤ 241.58 | 0.533 | (0.464, 0.601) | 47.86 | 66.67 | 62.9 | 52 | 14.53 | 0.405 |
 ML_I | ≤ 14.62 | 0.654 | (0.586, 0.717) | 53.85 | 81.82 | 77.8 | 60 | 35.66 | < 0.001* |
 GK | > 73.24 | 0.561 | (0.492, 0.628) | 66.67 | 51.52 | 61.9 | 56.7 | 18.18 | 0.122 |
 EF | > 14.2 | 0.586 | (0.517, 0.652) | 60.68 | 59.60 | 64 | 56.2 | 20.28 | 0.029* |
 SL | ≤ 1142.64 | 0.738 | (0.675, 0.796) | 70.09 | 69.70 | 73.2 | 66.3 | 39.78 | < 0.001* |
 SI | ≤ 5.25 | 0.553 | (0.484, 0.620) | 53.85 | 62.63 | 63 | 53.4 | 16.47 | 0.181 |
 RI | > 4.11 | 0.589 | (0.521, 0.656) | 51.28 | 67.68 | 65.2 | 54 | 18.96 | 0.022* |
 EI | ≤ 20 | 0.687 | (0.621, 0.748) | 52.99 | 88.89 | 84.9 | 61.5 | 41.88 | < 0.001* |
 Sir_I | ≤ 28.5 | 0.549 | (0.480, 0.617) | 31.62 | 82.83 | 68.5 | 50.6 | 14.45 | 0.209 |
 HH | > 25.84 | 0.606 | (0.538, 0.672) | 59.83 | 63.64 | 66 | 57.3 | 23.47 | 0.007* |
Qualitative hemoglobinopathy (sickle cell anemia) | |||||||||
 RDWI | ≤ 525 | 0.5 | (0.432–0.569) | 72 | 6.63 | 18.8 | 44 | 21.37 | 0.994 |
 ML_I | > 28.67 | 0.605 | (0.536–0.670) | 26 | 94.58 | 59.1 | 80.9 | 20.58 | 0.027* |
 GK | > 103.6 | 0.516 | (0.447–0.584) | 44 | 81.33 | 41.5 | 82.8 | 25.33 | 0.783 |
 EF | > 23.7 | 0.518 | (0.449–0.586) | 46 | 84.94 | 47.9 | 83.9 | 30.94 | 0.757 |
 SL | > 1243.8 | 0.760 | (0.698–0.816) | 76 | 71.08 | 44.2 | 90.8 | 47.08 | < 0.001* |
 SI | > 6.41 | 0.603 | (0.534–0.669) | 42 | 81.93 | 41.2 | 82.4 | 23.93 | 0.039* |
 RI | ≤ 2.88 | 0.558 | (0.489–0.625) | 38 | 89.76 | 52.8 | 82.8 | 27.76 | 0.299 |
 EI | > 34.9 | 0.647 | (0.579–0.711) | 50 | 74.10 | 36.8 | 83.1 | 24.1 | 0.001* |
 Sir_I | > 43.6 | 0.586 | (0.517–0.652) | 44 | 86.75 | 50 | 83.7 | 30.75 | 0.111 |
 HH | ≤ 22.37 | 0.528 | (0.459–0.596) | 44 | 81.93 | 42.3 | 82.9 | 25.93 | 0.611 |