The Egyptian Journal of Internal Medicine

Table 1 Differences among the study patients as regard demographic and clinical characteristics and transfusion dependency

From: Significance of the mathematically calculated red cell indices in patients with qualitative and quantitative hemoglobinopathies

Characteristics	Group			p-value
Characteristics	Thalassemia (Group 1A) 117 (54.2%)	Sickle cell anemia (Group 1B) 50 (23.1%)	IDA Group 2 49 (22.7%)	p-value
Age at onset (year)
Mean ± SD	21.77 ± 13.31	27.3 ± 12.59	33.12 ± 9.35	< 0.001*
Median (IQR)	18 (13–30)	26.5 (20–36.25)	32 (25–39.5)
Gender
Male	74 (63.2%)	29 (58%)	14 (28.6%)	< 0.001*
Female	43 (36.8%)	21 (42%)	35 (71.4%)
Governorate
Assiut	26 (22.2%)	10 (20%)	3 (6.1%)
Sohag	67 (57.3%)	31 (62%)	41 (83.7%)
El Minia	5 (4.3%)	2 (4%)	3 (6.1%)	0.120
Qena	5 (4.3%)	0 (0.0%)	2 (4.1%)
Aswan	4 (3.4%)	2 (4%)	0 (0.0%)
Red Sea	5 (4.3%)	3 (6%)	0 (0.0%)
Luxor	2 (1.7%)	1 (2%)	0 (0.0%)
New Valley	3 (2.6%)	1 (2%)	0 (0.0%)
Presentation
Acute hemolysis	47 (40.2%)	11 (22%)	0 (0.0%)
Painful crisis	0 (0.0%)	13 (26%)	0 (0.0%)
Acute abdomen	16 (13.7%)	4 (8%)	2 (4.1%)
Anemic symptoms	34 (29.1%)	7 (14%)	30 (61.2%)	< 0.0001*
Huge splenomegaly	3 (2.6%)	0 (0.0%)	0 (0.0%)
Jaundice	15 (12.8%)	2 (4%)	0 (0.0%)
ACS	0 (0.0%)	2 (4%)	0 (0.0%)
Obstructive jaundice	2 (1.7%)	11 (22%)	2 (4.1%)
Chronic bleeding	0 (0.0%)	0 (0.0%)	15 (30.6%)
Transfusion dependency				< 0.0001*
Dependent	65 (55.6%)	1 (2%)	0 (0.0%)
Independent	52 (44.4%)	49 (98%)	49 (100%)

*Statistically significant at 5%. IDA iron deficiency anemia, ACS acute chest syndrome, SD standard deviation, IQR interquartile range

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