Table 6 Pooled frequency of the symptoms

Weight loss

65

60–70

<0.0001

99

6097

−8.29

Heat intolerance

64

58–70

<0.0001

99

3250

−8.90

Palpitations

69

62–77

<0.0001

100

8536

−5.75

Excessive sweating

48

29–67

<0.0001

100

26,649

−5.3

Tiredness

49

38–60

<0.0001

98

648

1.12

Increased appetite

49

38−60

<0.0001

97

678

1.12

Hyperdefecation

37

23–51

<0.0001

98

856

1.93

Insomnia

47

36–59

<0.0001

97

595

−0.8

Nervousness

41

32–49

<0.0001

99

2919

8.86

Irritability

25

16–36

<0.0001

96

268

5.65

Oligomenorrhea

23

13–34

<0.0001

94

181

0.15

Dyspnea

40

7–78

<0.0001

99

1582

2.58

Psychotic symptoms

3

0–7

<0.0001

92

35

2.64

Skin darkening

15

6–26

<0.0001

96

117

2.22

Weight gain

3

1–5

<0.0001

45

3.62

0.08

Infertility

26

0–86

<0.0001

99

212

1.115

Hair loss

13

5–24

<0.0001

95

82

2.92

Pruritus

9

6–13

<0.0001

1

0.3

–

Persistent headache

5

2–8

<0.0001

30

1.43

–

Menorrhagia

5

3–8

<0.0001

0

0.34

1.22