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Table 1 Levels of hemoglobin fractions of hemoglobinopathy patients attending Aga Khan Hospital Kisumu, western Kenya, and its satellites

From: High-performance liquid chromatography local reference ranges of hemoglobin fractions (HbA, HbA2, and HbF) in detection of hemoglobinopathies in western Kenya

Characteristics

Levels of hemoglobin fractions

HbA (%)

p

HbA2 (%)

p

HbF (%)

p

P window (%)

p

Median (IQR)

95% CI

Median (IQR)

95% CI

Median (IQR)

95% CI

Median (IQR)

95% CI

Overall (N = 386)

87.7 (5.7)

76.3–99.1

 

3.0 (0.6)

1.8–4.2

 

0.8 (0.8)

0.0–2.4

 

4.98 (0.4)

4.18–5.78

 

Station

Busia (n = 52) 13.5%

86.3 (4.9)

76.5–96.1

0.016

3.2 (1.03)

1.14–5.26

< 0.0001

0.8 (0.8)

0.0–2.4

< 0.0001

5.1 (0.67)

3.76–6.44

0.020

Bungoma (n = 49) 12.7%

88.4 (5.0)

78.4–98.4

3.3 (0.5)

2.3–4.3

0.8 (0.1)

0.6–1.00

4.9 (0.54) 3.82–5.98

Kitale (n = 18) 4.7%

86.2 (2.8)

80.6–91.8

3.2 (0.9)

1.4–5.0

0.8 (0.65)

0.0–2.1

4.99 (0.92)

3.15–6.83

Kakamega (n = 15) 3.9%

90.4 (6.2)

78.0–102.8

2.8 (1.3)

0.2–5.4

0.5 (1.10)

0.0–2.7

4.98 (0.44)

4.1–5.86

Kisumu (n = 182) 47.2%

88.5 (6.0)

76.5–100.5

3.0 (0.6)

1.8–4.2

0.8 (0.8)

0.0–2.4

4.98 (0.3)

4.38–5.58

Kisii (n = 32) 8.3%

87.2 (3.5)

80.2–94.2

3.0 (1.1)

0.8–5.2

0.8 (0.58)

0.0–1.96

5.0 (0.7)

3.6–6.4

Homabay (n = 32) 8.3%

85.5 (6.5)

72.7–98.5

3.0 (0.65)

1.7–4.3

0.8 (1.05)

0.0–2.9

5.0 (0.53)

3.94–6.06

Migori (n = 6) 1.6%

85.0 (8.0)

69–101

2.9 (0.5)

1.9–3.9

2.1 (0.7)

0.7–3.5

4.99 (1.8)

1.39–8.59

Gender

Male (n = 185) 47.9%

86.9 (5.2)

76.5–97.3

0.005

3.0 (0.6)

1.8–4.2

0.901

0.8 (0.8)

0.0–2.4

0.075

4.98 (0.63)

3.72–6.24

0.514

Female (n = 201) 52.1%

88.5 (5.4)

77.7–99.3

3.0 (0.6)

1.8–4.2

0.8 (0.8)

0.0–2.4

4.98 (0.34)

4.3–5.66

Age

≤ 2 years (n = 115) 29.8%

87.7 (6.2)

75.3–100.1

0.106

3.0 (0.8)

1.4–4.6

0.219

1.0 (0.8)

0.0––2.6

< 0.0001

5.0 (0.5)

4.0–6.0

0.259

3–5 years (n = 49) 12.7%

86.7 (5.8)

75.1–98.3

3.1 (0.8)

1.5–4.7

0.8 (0.8)

0.0–2.4

4.98 (0.8)

3.38–6.58

6–11 years (n = 46) 11.9%

87.8 (6.1)

75.6–100

3.15 (0.6)

1.95–4.35

0.8 (0.03)

0.74–0.86

4.98 (0.46)

4.06–5.9

≥ 12 years (n = 176) 45.6%

88.5 (5.4)

77.7–99.3

3.0 (0.7)

1.6–4.4

0.55 (0.8)

0.0–2.15

4.98 (0.4)

4.18–5.78