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Table 3 Comparison between renal SLEDAI groups regarding the laboratory tests

From: Vitamin D in active systemic lupus erythematosus and lupus nephritis: a forgotten player

Variable

Renal SLEDAI (negative) “n = 32”

Renal SLEDAI (positive) “n = 68”

P value

AST (U/L)

21.56 ± 9.05

24.67 ± 20.23

0.43

ALT (U/L)

18.75 ± 12.57

21.26 ± 24.50

0.4

ALP (IU/L)

57.31 ± 14.79

84.88 ± 63.78

0.03*

CPK (U/L)

106.69 ± 146.50

68.29 ± 27.64

0.02*

LDH (U/L)

286.69 ± 71.40

329.26 ± 148.62

0.09

Serum albumin (g/dl)

42.13 ± 4.61

36.03 ± 7.63

0.04*

A/G ratio

1.32 ± 0.39

1.11 ± 0.30

0.42

Glucose (mmol/L)

5.08 ± 1.57

5.80 ± 7.14

0.4

Urea (mmol/L)

4.69 ± 1.88

6.32 ± 5.04

0.08

Creatinine (μmol/L)

48.4 ± 16.08

87.68 ± 141.82

0.15

Serum total cholesterol (mg/dl)

167.25 ± 35.43

168.97 ± 48.88

0.41

Triglyceride (mg/dl)

136.06 ± 131.44

134.12 ± 89.17

0.89

HDL-C (mg/dl)

47.85 ± 14.31

43.38 ± 16.44

0.48

LDL-C(mg/dl)

90.11 ± 40.73

99.24 ± 39.87

0.97

Creatinine Clearance (ml/min)

93.97 ± 40.15

103.33 ± 46.61

0.87

24 h protein in urine (mg)

312.43 ± 129.10

1581.81 ± 1886.05

0.003**

Pus/HPF in urine

  

0.002**

negative

16 (100%)

12 (35.3%)

 

positive

0 (0%)

22 (64.7%)

 

RBCs in urine

  

0.001**

negative

16 (100%)

15 (44.1%)

 

positive

0 (0%)

19 (55.9%)

 

Urinary cast

  

0.13

negative

16 (100%)

29 (85.3%)

 

positive

0 (0%)

5 (14.7%)

 

Crystals in urine

  

0.27

negative

15 (93.8%)

28 (82.4%)

 

positive

1 (6.2%)

6 (17.6%)

 

Albumin in urine

  

0.004**

negative

14 (87.5%)

15 (44.1%)

 

positive

2 (12.5%)

19 (55.9%)

 

C3 (μg/ml)

3.74 ± 2.67

3.23 ± 3.06

0.963

C4 (μg/ml)

3.05 ± 2.22

1.83 ± 1.45

0.098

Anti-dsDNA

1.52 ± 1.34

2.22 ± 1.65

0.987

25(OH)D (ng/ml)

5.07 ± 3.10

2.58 ± 1.82

0.003***

  1. Data are presented as mean ± SD. The independent samples t test was used to compare between means of different parameters in SLEDAI groups. P value < 0.05 is considered to be a significant value
  2. SD standard deviation, SLEDAI systemic lupus erythematosus disease activity index, AST aspartate transaminase, ALT alanine transaminase, ALP alkaline phosphatase, CPK creatinine phosphokinase, LDH lactate dehydrogenase, A/G ratio albumin globulin ratio, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HPF high power field, C3 complement 3, C4 complement 4, Anti-dsDNA anti-d double-stranded deoxyribonucleic acid, 25(OH)D 25 hydroxyvitamin D
  3. *Statistically significant (P < 0.05)
  4. **Moderately statistically significant (P < 0.01)
  5. ***Highly statistically significant (P < 0.001)