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Table 2 Comparison between SLEDAI groups regarding the laboratory tests

From: Vitamin D in active systemic lupus erythematosus and lupus nephritis: a forgotten player

Variable

SLEDAI < 8 “n = 18”

SLEDAI ≥ 8 “n = 82”

P value

ESR (mm/1st h)

40 ± 29.82

49.54 ± 30.97

0.93

CRP (mg/L)

9.02 ± 15.71

11.21 ± 18.56

0.83

Hb (g/dl)

11.22 ± 1.16

10.87 ± 1.63

0.55

RBCs (103/μl)

3.90 ± 0.90

4.27 ± 0.69

0.18

WBCs (103/μl)

5.30 ± 2.42

5.26 ± 2.35

0.96

Platelets (103/μl)

286.33 ± 100.18

280.34 ± 114.63

0.88

AST (U/L)

22.56 ± 9.40

23.92 ± 8.79

0.83

ALT (U/L)

25.11 ± 16.51

19.44 ± 3.47

0.47

ALP (IU/L)

87.33 ± 15.85

73.59 ± 53.79

0.50

CPK (U/L)

133.89 ± 64.09

68.88 ± 30.08

0.03*

LDH (U/L)

289.44 ± 94.65

321.39 ± 136.55

0.51

Serum albumin (g/dl)

40.12 ± 4.01

37.50 ± 7.85

0.34

A/G ratio

1.24 ± 0.311

1.16 ± 0.35

0.53

Glucose (mmol/L)

4.88 ± 1.13

5.71 ± 1.02

0.71

Urea (mmol/L)

4.20 ± 1.36

6.15 ± 0.73

0.23

Creatinine (μmol/L)

49.80 ± 14.34

80.66 ± 20.29

0.48

Serum TC(mg/dl)

151.55 ± 31.33

172.12 ± 46.56

0.21

serum TG(mg/dl)

109.00 ± 46.48

140.39 ± 17.40

0.48

HDL-c (mg/dl)

40.97 ± 7.45

45.64 ± 17.03

0.43

LDL-c (mg/dl)

88.11 ± 23.08

98.11 ± 42.79

0.50

Creatinine Clearance (ml/min)

86.24 ± 38.95

103.43 ± 45.41

0.30

24 h protein in urine (mg)

723.04 ± 272.82

1275.0 ± 278.89

0.37

Pus/HPF in urine

negative

7(77.8%)

21(51.2%)

0.14

positive

2(22.2%)

20(48.8%)

 

RBCs in urine

negative

7(77.8%)

24(58.5%)

0.25

positive

2(22.2%)

17(41.5%)

 

Urinary cast

negative

8(88.9%)

37(90.2%)

0.65

positive

1(11.1%)

4(9.8%)

 

Crystals in urine

negative

7(77.8%)

36(87.8%)

0.37

positive

2(22.2%)

5(12.2%)

 

Albumin in urine

negative

6(66.7%)

23(56.1%)

0.42

positive

3(33.3%)

18(43.9%)

 

C3 (μg/ml)

4.77 ± 2.16

3.09 ± 2.36

0.119

C4 (μg/ml)

4.40 ± 1.88

2.06 ± 1.21

0.000***

Anti-dsDNA

1.34 ± 1.20

2.14 ± 1.62

0.170

25(OH)D (ng/ml)

5.10 ± 3.19

3.00 ± 2.27

0.02*

  1. Data are presented as numbers (n) and mean ± SD (standard deviation). The independent samples t test was used to compare between means of different parameters in SLEDAI groups. P value < 0.05 is considered to be a significant value
  2. SLEDAI systemic lupus erythematosus disease activity index, ESR erythrocyte sedimentation rate, CRP C- reactive protein, Hb hemoglobin, RBCs red blood cells, WBCs white blood cells, AST aspartate transaminase, ALT alanine transaminase, ALP alkaline phosphatase, CPK creatinine phosphokinase, LDH lactate dehydrogenase, A/G ratio albumin globulin ratio, TC total cholesterol, TG triglyceride, HDL high-density lipoproteins, LDL low-density lipoproteins, HPF high power field, C3 complement 3, C4 complement 4, Anti-dsDNA anti-d double-stranded deoxyribonucleic acid, 25(OH)D 25 hydroxyvitamin D
  3. *Statistically significant (P < 0.05)
  4. ***Highly statistically significant (P < 0.001)